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Central Nervous System Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Anti-Inflammatory Effects of Antidepressants: Possibilities for Preventives Against Alzheimers Disease

Author(s): Sadayuki Hashioka, Patrick L. McGeer, Akira Monji and Shigenobu Kanba

Volume 9, Issue 1, 2009

Page: [12 - 19] Pages: 8

DOI: 10.2174/187152409787601897

Price: $65

Abstract

Increasing evidence of pro-inflammatory mediator expression in major depressions indicate that inflammatory changes may play a role. If this is true, the efficacy of antidepressants may be partially attributable to suppression of inflammation. Various types of antidepressants can suppress serum and plasma levels of pro-inflammatory mediators in patients with major depression. Therefore they can inhibit the production of pro-inflammatory mediators by immune cells. These include glial cells, which are the main sources and targets of cytokines in the brain. This review summarizes the evidence showing that antidepressants have an anti-inflammatory potential. The putative mechanisms are also discussed. Because of the anti-inflammatory effects of antidepressants, they might also act as preventives for neurodegenerative dementias including Alzheimers disease, where the pathogenesis involves chronic inflammation associated with activated microglia.

Keywords: Antidepressants, major depression, Alzheimer's disease, inflammation, cytokines, microglia


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