Abstract
A novel human Glyco_18 domain – containing protein, SI-CLP, was detected recently in human bronchoalveolar lavage of patients with chronic inflammatory disorders of the respiratory tract and peripheral-blood leukocytes. The expression of SI-CLP is up-regulated by dexamethasone or IL-4 and involved in the Th2 cell pathway. To further investigate its structure and function will provide new insights into human immunity and related disorders. Here we provide a preliminary crystal image of SI-CLP using the hanging-drop vapor diffusion method. The crystals of SI-CLP diffracted Xrays to a resolution of 2.7 Å. The crystals belong to the space group P3221 with unit cell parameters a = b =99.79 Å, c =250.53 Å, α=β=90°, γ=120°. There are two molecules per asymmetry unit.
Keywords: Homo sapiens, protein crystallography, SI-CLP
Protein & Peptide Letters
Title: Crystallization and Preliminary X-Ray Crystallographic Studies on SICLP, a Novel Human Glyco_18 Domain – Containing Protein
Volume: 16 Issue: 3
Author(s): Geng Meng, Xiaoyun Bai, Todd J. Green, Ming Luo and Xiaofeng Zheng
Affiliation:
Keywords: Homo sapiens, protein crystallography, SI-CLP
Abstract: A novel human Glyco_18 domain – containing protein, SI-CLP, was detected recently in human bronchoalveolar lavage of patients with chronic inflammatory disorders of the respiratory tract and peripheral-blood leukocytes. The expression of SI-CLP is up-regulated by dexamethasone or IL-4 and involved in the Th2 cell pathway. To further investigate its structure and function will provide new insights into human immunity and related disorders. Here we provide a preliminary crystal image of SI-CLP using the hanging-drop vapor diffusion method. The crystals of SI-CLP diffracted Xrays to a resolution of 2.7 Å. The crystals belong to the space group P3221 with unit cell parameters a = b =99.79 Å, c =250.53 Å, α=β=90°, γ=120°. There are two molecules per asymmetry unit.
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Cite this article as:
Meng Geng, Bai Xiaoyun, Green J. Todd, Luo Ming and Zheng Xiaofeng, Crystallization and Preliminary X-Ray Crystallographic Studies on SICLP, a Novel Human Glyco_18 Domain – Containing Protein, Protein & Peptide Letters 2009; 16 (3) . https://dx.doi.org/10.2174/092986609787601660
DOI https://dx.doi.org/10.2174/092986609787601660 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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