Abstract
A derivative of gossypol, 6,7,6,7-Tetrahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2] binaphthalenyl- 1,4,1,4-tetraone (Apogossypolone, ApoG2), has been synthesized from gossypol acetic acid. Its structure was identified by IR, NMR, MS spectrum and cancer cells in vitro growth inhibition experiments were performed. The results indicate that apogossypolone exerts strong in vitro growth inhibition in human prostate cancer cells, representing a promising cancer therapeutic.
Keywords: Gossypol, Apogossypolone, Synthesis, In vitro growth inhibition, Proteins
Letters in Drug Design & Discovery
Title: A Novel Synthesis Method of Apogossypolone and its Antitumor Activity
Volume: 6 Issue: 2
Author(s): Yonghua Zhan and Guangfeng Jia
Affiliation:
Keywords: Gossypol, Apogossypolone, Synthesis, In vitro growth inhibition, Proteins
Abstract: A derivative of gossypol, 6,7,6,7-Tetrahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2] binaphthalenyl- 1,4,1,4-tetraone (Apogossypolone, ApoG2), has been synthesized from gossypol acetic acid. Its structure was identified by IR, NMR, MS spectrum and cancer cells in vitro growth inhibition experiments were performed. The results indicate that apogossypolone exerts strong in vitro growth inhibition in human prostate cancer cells, representing a promising cancer therapeutic.
Export Options
About this article
Cite this article as:
Zhan Yonghua and Jia Guangfeng, A Novel Synthesis Method of Apogossypolone and its Antitumor Activity, Letters in Drug Design & Discovery 2009; 6 (2) . https://dx.doi.org/10.2174/157018009787582589
DOI https://dx.doi.org/10.2174/157018009787582589 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Radiolabeled Compounds in the Development of Cytotoxic Agents
Current Pharmaceutical Design Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues
Current Medicinal Chemistry Recent Developments in Boron Neutron Capture Therapy (BNCT) Driven by Nanotechnology
Current Chemical Biology Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression
Anti-Cancer Agents in Medicinal Chemistry Star Graphs of Protein Sequences and Proteome Mass Spectra in Cancer Prediction
Current Proteomics Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders
Current Neuropharmacology Overview of Proteasome Inhibitor-Based Anti-cancer Therapies: Perspective on Bortezomib and Second Generation Proteasome Inhibitors versus Future Generation Inhibitors of Ubiquitin-Proteasome System
Current Cancer Drug Targets 3-Carboranyl Thymidine Analogues (3CTAs) and Other Boronated Nucleosides for Boron Neutron Capture Therapy
Anti-Cancer Agents in Medicinal Chemistry Prostate Cancer Gene Regulatory Network Inferred from RNA-Seq Data
Current Genomics Functional Food: Product Development and Health Benefits
Recent Patents on Engineering Tumor-Targeting Peptides and Small Molecules as Anti-Cancer Agents to Overcome Drug Resistance
Current Medicinal Chemistry Novel Therapeutic Strategies Against Cancer: Marine-derived Drugs May Be the Answer?
Anti-Cancer Agents in Medicinal Chemistry Curcumin Sensitizes Cancers Towards TRAIL-induced Apoptosis via Extrinsic and Intrinsic Apoptotic Pathways
Current Drug Targets Efficient Silencing of Hepatitis B Virus by Helper-dependent Adenovirus Vector-mediated Delivery of Artificial Antiviral Primary Micro RNAs
MicroRNA Targeting Cancer: The Challenges and Successes of Structure-Based Drug Design Against the Human Purinome
Current Topics in Medicinal Chemistry Therapeutic Use of MicroRNAs in Cancer
Anti-Cancer Agents in Medicinal Chemistry Natural Endoperoxides as Drug Lead Compounds
Current Medicinal Chemistry The Sodium-Iodide Symporter
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The Gastrin-Releasing Peptide Receptor as a Therapeutic Target in Central Nervous System Disorders
Recent Patents on CNS Drug Discovery (Discontinued) The Role of Insulin Resistance and Hyperinsulinemia in Cancer Causation
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents