Physical Stability of PLGA Microparticles for DNA Encapsulation

Title: Physical Stability of PLGA Microparticles for DNA Encapsulation

Volume: 6 Issue: 2

Author(s): Itziar Migueliz, Sonsoles Diez, Gemma Navarro and Conchita Tros de ILarduya

Affiliation:

Keywords: Stability, Poly (D,L-lactic-co-glycolic acid) (PLGA), Microparticles, Gene delivery, Biodegradable polymers, Microencapsulation

Abstract: In this study, we have evaluated the stability of poly (D,L-lactide-co-glycolide) (PLGA)-DNA microparticles prepared by using several types of polymers (RG502, RG503, RG504, RG502H, and RG752). Particles were characterised in terms of size, zeta potential, morphology and structural integrity just immediately after preparation, after lyophilisation and after 2 years of storage at -20°C. DNA has been demonstrated to be sufficiently stable for efficient incorporation into PLGA microparticles at least for 2 years after lyophilisation.

Cite this article as:

Migueliz Itziar, Diez Sonsoles, Navarro Gemma and de ILarduya Tros Conchita, Physical Stability of PLGA Microparticles for DNA Encapsulation, Letters in Drug Design & Discovery 2009; 6 (2) . https://dx.doi.org/10.2174/157018009787582679