Abstract
Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.
Keywords: WNT, rheumatoid arthritis, FRP, β-catenin, synovium, matrix metalloproteinase
Mini-Reviews in Medicinal Chemistry
Title: The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication
Volume: 9 Issue: 3
Author(s): Kazushi Imai, Tadashige Chiba, Genta Maeda and Masako Morikawa
Affiliation:
Keywords: WNT, rheumatoid arthritis, FRP, β-catenin, synovium, matrix metalloproteinase
Abstract: Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.
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Cite this article as:
Imai Kazushi, Chiba Tadashige, Maeda Genta and Morikawa Masako, The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication, Mini-Reviews in Medicinal Chemistry 2009; 9 (3) . https://dx.doi.org/10.2174/1389557510909030318
DOI https://dx.doi.org/10.2174/1389557510909030318 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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