A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions

Title: A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions

Volume: 4 Issue: 1

Author(s): Kedsuda Apichonbancha, Bhaskar Dasgupta, Jin Jun, Ion Mandoiu and Emma Mendonca

Affiliation:

Keywords: Primer approximation multiplex pcr, cancer genomic lesions, efficient algorithms

Abstract: Primer Approximation Multiplex PCR (PAMP) is a recently introduced experimental technique for detecting large-scale cancer genome lesions such as inversions and deletions from heterogeneous samples containing a mixture of cancer and normal cells. In this chapter we will first review previous solutions for the problem of selecting sets of PAMP primers that minimize detection failure probability and subsequently review our approach based on integer programming formulations for inversion and deletion detections.

Cite this article as:

Apichonbancha Kedsuda, Dasgupta Bhaskar, Jun Jin, Mandoiu Ion and Mendonca Emma, A Review of the Primer Approximation Multiplex PCR (PAMP) Technique for Detecting Large Scale Cancer Genomic Lesions, Current Bioinformatics 2009; 4 (1) . https://dx.doi.org/10.2174/157489309787158161