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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Oncomirs: From Tumor Biology to Molecularly Targeted Anticancer Strategies

Author(s): Simone Mocellin, Sandro Pasquali and Pierluigi Pilati

Volume 9, Issue 1, 2009

Page: [70 - 80] Pages: 11

DOI: 10.2174/138955709787001802

Price: $65

Abstract

Deregulation of microRNA (miRNA) promotes carcinogenesis, as these molecules can act as oncogenes or tumor suppressor genes. Here we provide an overview of miRNA biology, discuss the most recent findings on miRNA and cancer development/progression, and report on how tumor-related miRNAs (oncomirs) are being used to develop novel cancer specific therapeutic approaches.

Keywords: MicroRNA, miRNA, oncomirs, cancer biology, molecular targets, anticancer therapeutics


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