Microwave-Assisted Synthesis of Imido-Substituted 2-Chloro-1,4-naphthoquinone Derivatives and their Cytotoxic Activities on Three Human Prostate Cancer Cell Lines

Title: Microwave-Assisted Synthesis of Imido-Substituted 2-Chloro-1,4-naphthoquinone Derivatives and their Cytotoxic Activities on Three Human Prostate Cancer Cell Lines

Volume: 5 Issue: 8

Author(s): Solomon Berhe, Yasmine Kanaan, Robert L. Copeland Jr., Dwayne A. Wright, Leon H. Zalkow and Oladapo Bakare

Affiliation:

Keywords: Prostate cancer, 2-Chloro-1, 4-naphthoquinone, Imides, Microwave-assisted synthesis

Abstract: The anticancer activities of six imido-substituted 2-chloro-1,4-naphthoquinone derivatives on one androgendependent, LNCaP, and two androgen-independent, PC3 and DU145, human prostate cancer cell lines are reported. The open chain imides (2-4) showed more potency in all three cell lines. In addition the microwave-assisted synthesis of five of these compounds is reported.

Cite this article as:

Berhe Solomon, Kanaan Yasmine, Copeland Jr. L. Robert, Wright A. Dwayne, Zalkow H. Leon and Bakare Oladapo, Microwave-Assisted Synthesis of Imido-Substituted 2-Chloro-1,4-naphthoquinone Derivatives and their Cytotoxic Activities on Three Human Prostate Cancer Cell Lines, Letters in Drug Design & Discovery 2008; 5 (8) . https://dx.doi.org/10.2174/157018008786898581