Metal Free One Pot Approach Towards the Synthesis of Hantzsch Esters and their Application as the Hydrogen Source for the Reduction of Activated Olefins Catalysed by Bromo Dimethyl Sulfonium Bromide (BDMS)

Title: Metal Free One Pot Approach Towards the Synthesis of Hantzsch Esters and their Application as the Hydrogen Source for the Reduction of Activated Olefins Catalysed by Bromo Dimethyl Sulfonium Bromide (BDMS)

Volume: 5 Issue: 8

Author(s): Papori Goswami, Shahzad Ali, Md. M. Khan and Babulal Das

Affiliation:

Keywords: Hantzsch esters, metal free catalyst, β-ketoester, reducing agents, dihydropyridines, substituent effects

Abstract: An environmentally benign one pot synthesis of dihydropyridines and its use as hydrogen source in the reduction of α,β-unsaturated aldehydes and ketones using catalytic amount of BDMS at room temperature is described. An extensive study on the role of substituents on aldehyde for the formation of Hantzsch esters, reveals that presence of more than one electron donating substituents, hinders the formation of dihydropyridine derivative.

Cite this article as:

Goswami Papori, Ali Shahzad, Khan M. Md. and Das Babulal, Metal Free One Pot Approach Towards the Synthesis of Hantzsch Esters and their Application as the Hydrogen Source for the Reduction of Activated Olefins Catalysed by Bromo Dimethyl Sulfonium Bromide (BDMS), Letters in Organic Chemistry 2008; 5 (8) . https://dx.doi.org/10.2174/157017808786857507