Abstract
Chronic obstructive pulmonary disease (COPD) currently ranks as the fourth cause of death in the United States and it is an increasingly important health problem for the rest of the world [1-3]. Its prevalence has increased as overall mortality from myocardial infarction and cerebro-vascular accident, the two organ system affected by the same risk factor (namely cigarette smoking), have decreased. Although preventable and treatable, once diagnosed and symptomatic COPD is progressive and in some patients leads to disability usually due to dyspnea, at a relatively early age (6th or 7th decade) [4,5]. Limitation to airflow occurs as a consequence of destruction of lung parenchyma or to alterations in the airway itself. One of the most important consequences is the development of static and dynamic hyperinflation with important clinical consequences such as dyspnea with exercise and decreased survival. This chapter integrates the pathologic changes of COPD with the known adaptive and maladaptive consequences of those changes. These factors should help us understand the rationale behind the therapeutic strategies aimed at decreasing lung volume and addressing the complications of patients with COPD.
Keywords: Dyspnea, dynamic hyperinflation, respiratory drive, oxygen, flow limitation, respiratory muscles, lung volume reduction surgery
Current Respiratory Medicine Reviews
Title: Lung Volume Reduction in Patients with COPD: Physiological and Clinical Implications
Volume: 4 Issue: 4
Author(s): Bartolome R. Celli
Affiliation:
Keywords: Dyspnea, dynamic hyperinflation, respiratory drive, oxygen, flow limitation, respiratory muscles, lung volume reduction surgery
Abstract: Chronic obstructive pulmonary disease (COPD) currently ranks as the fourth cause of death in the United States and it is an increasingly important health problem for the rest of the world [1-3]. Its prevalence has increased as overall mortality from myocardial infarction and cerebro-vascular accident, the two organ system affected by the same risk factor (namely cigarette smoking), have decreased. Although preventable and treatable, once diagnosed and symptomatic COPD is progressive and in some patients leads to disability usually due to dyspnea, at a relatively early age (6th or 7th decade) [4,5]. Limitation to airflow occurs as a consequence of destruction of lung parenchyma or to alterations in the airway itself. One of the most important consequences is the development of static and dynamic hyperinflation with important clinical consequences such as dyspnea with exercise and decreased survival. This chapter integrates the pathologic changes of COPD with the known adaptive and maladaptive consequences of those changes. These factors should help us understand the rationale behind the therapeutic strategies aimed at decreasing lung volume and addressing the complications of patients with COPD.
Export Options
About this article
Cite this article as:
Celli R. Bartolome, Lung Volume Reduction in Patients with COPD: Physiological and Clinical Implications, Current Respiratory Medicine Reviews 2008; 4 (4) . https://dx.doi.org/10.2174/157339808786263734
DOI https://dx.doi.org/10.2174/157339808786263734 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review
Current Stem Cell Research & Therapy Biological Markers in Older People at Risk of Mobility Limitations
Current Pharmaceutical Design Clopidogrel, Aspirin and Proton Pump Inhibition after Percutaneous Valve Implants: An Update
Current Pharmaceutical Design The Importance of Novel Inflammatory Biomarkers in Renal Disease
Current Medicinal Chemistry Nanomedicine based on Nucleic Acids: Pharmacokinetic and Pharmacodynamic Perspectives
Current Pharmaceutical Biotechnology Physiology of Folic Acid in Health and Disease
Current Drug Metabolism Antiangiogenic Therapy in Malignant Glioma: Promise and Challenge
Current Pharmaceutical Design Chronic Complications of Diabetes Mellitus: A Mini Review
Current Diabetes Reviews Inflammation and Immunology of the Vitreoretinal Compartment
Inflammation & Allergy - Drug Targets (Discontinued) Proteins in Pharmacology: Restrictions, Challenges and Opportunities
Current Medicinal Chemistry Extracellular Proteases as Targets for Drug Development
Current Protein & Peptide Science Application of Transcranial Color-Coded Duplex Sonography in Stroke Diagnosis
Current Medical Imaging Recommendations for the Use of Therapeutic Plasma
Current Vascular Pharmacology Arterial Hyperoxia in Severe Head Injury: A Useful or Harmful Option?
Current Pharmaceutical Design Strategies to Avoid TAVI-related Acute Kidney Injury
Current Pharmaceutical Design Biophysics of Venous Return from the Brain from the Perspective of the Pathophysiology of Chronic Cerebrospinal Venous Insufficiency
Reviews on Recent Clinical Trials L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?
Letters in Drug Design & Discovery Endothelial Dysfunction in Morbid Obesity
Current Pharmaceutical Design Nanoparticles for the Treatment of Wounds
Current Pharmaceutical Design Prevalence and Prognostic Value of Depression and Anxiety in Patients with Diabetic Foot Ulcers and Possibilities of their Treatment
Current Diabetes Reviews