Abstract
The inability to engage in the usual activities of daily living is one of the most distressing experiences of people afflicted with chronic obstructive pulmonary disease (COPD). Exercise intolerance progresses relentlessly as the disease advances, contributing to reduced quality of life. It has become clear that in COPD, exercise intolerance ultimately reflects complex integrated abnormalities of the ventilatory, cardiovascular, peripheral muscle and neurosensory systems that vary in degree from patient to patient. Ventilatory limitation and perceived respiratory difficulty are often the dominant contributors to exercise curtailment in more advanced disease, but not necessarily the only ones. Recently, there has been great interest in the role of cardiovascular and peripheral muscle dysfunction (and their interaction) in exercise limitation in COPD. In this review, we examine in some detail the pathophysiological derangements that are evident during exercise in COPD with the hope of identifying specific mechanisms that are amenable to therapeutic manipulation.
Keywords: COPD, exercise, ventilatory mechanics, dyspnea, dynamic hyperinflation, muscle dysfunction, energy metabolism
Current Respiratory Medicine Reviews
Title: Exercise Limitation in Chronic Obstructive Pulmonary Disease
Volume: 4 Issue: 4
Author(s): Pierantonio Laveneziana, Karin Wadell, Katherine Webb and Denis E. O'Donnell
Affiliation:
Keywords: COPD, exercise, ventilatory mechanics, dyspnea, dynamic hyperinflation, muscle dysfunction, energy metabolism
Abstract: The inability to engage in the usual activities of daily living is one of the most distressing experiences of people afflicted with chronic obstructive pulmonary disease (COPD). Exercise intolerance progresses relentlessly as the disease advances, contributing to reduced quality of life. It has become clear that in COPD, exercise intolerance ultimately reflects complex integrated abnormalities of the ventilatory, cardiovascular, peripheral muscle and neurosensory systems that vary in degree from patient to patient. Ventilatory limitation and perceived respiratory difficulty are often the dominant contributors to exercise curtailment in more advanced disease, but not necessarily the only ones. Recently, there has been great interest in the role of cardiovascular and peripheral muscle dysfunction (and their interaction) in exercise limitation in COPD. In this review, we examine in some detail the pathophysiological derangements that are evident during exercise in COPD with the hope of identifying specific mechanisms that are amenable to therapeutic manipulation.
Export Options
About this article
Cite this article as:
Laveneziana Pierantonio, Wadell Karin, Webb Katherine and O'Donnell E. Denis, Exercise Limitation in Chronic Obstructive Pulmonary Disease, Current Respiratory Medicine Reviews 2008; 4 (4) . https://dx.doi.org/10.2174/157339808786263752
DOI https://dx.doi.org/10.2174/157339808786263752 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Therapeutic Potential of Hepatocyte Growth Factor for Myocardial Infarction and Heart Failure
Current Pharmaceutical Design GLP-1RA and SGLT2i: Cardiovascular Impact on Diabetic Patients
Current Hypertension Reviews The Problem of Atrial Fibrillation in Patients with Chronic Kidney Disease
Current Vascular Pharmacology Targeting Calcium and the Mitochondria in Prevention of Pathology in the Heart
Current Drug Targets The Electrocardiographic Manifestations of Arrhythmogenic Right Ventricular Dysplasia
Current Cardiology Reviews Family History and Preclinical Atherosclerosis
Current Hypertension Reviews Blood Pressure and Cognitive Impairment in the Elderly
Current Hypertension Reviews Schizophrenia and the Neglect Syndrome: Parietal Contributions to Cognitive Dysfunction in Schizophrenia
Current Psychiatry Reviews Endocrinological Aspects of Proteinuria and Podocytopathy in Diabetes: Role of the Aldosterone/Mineralocorticoid Receptor System
Current Diabetes Reviews Role of Renin-Angiotensin System in Inflammation, Immunity and Aging
Current Pharmaceutical Design Pulmonary Hypertension in Cardiac Surgery
Current Cardiology Reviews Coronary Risk Assessment and Management Options in Chronic Kidney Disease Patients Prior to Kidney Transplantation
Current Cardiology Reviews NLRP3 Is Involved in Ischemia/Reperfusion Injury
CNS & Neurological Disorders - Drug Targets Occurrence and Clinical Impact of Microembolic Signals (MES) in Patients with Chronic Cardiac Diseases and Atheroaortic Plaques - A Systematic Review
Current Vascular Pharmacology Sympathetic Activation in Congestive Heart Failure: Evidence, Consequences and Therapeutic Implications
Current Vascular Pharmacology Endotoxin, Toll-like Receptor-4, and Atherosclerotic Heart Disease
Current Cardiology Reviews Cardiovascular Effects of EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibodies
Cardiovascular & Hematological Agents in Medicinal Chemistry Cholesterol Lowering Therapy: Treat to Target or Reduce the Global Risk? The Unresolved Problem of Residual Risk
Current Pharmaceutical Design Nitroso-Redox Balance and Modulation of Basal Myocardial Function: An Update from the Italian Society of Cardiovascular Research (SIRC)
Current Drug Targets On Some Physiological Aspects of Ethanol Repercussion on Neural and Cardiorenal Functions
Central Nervous System Agents in Medicinal Chemistry