Abstract
Our laboratory and others have documented in some detail the immunological consequences which follow from interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R (expressed predominantly on cells of myeloid and lymphoid origin). In particular, there is evidence that these interactions lead to immunosuppressive signals which modulate graft rejection responses; decrease the manifestations of arthritis in rodent models; diminish mast cell mediator release in models of allergic disease; and favour the growth of tumors in both mice and humans. The development of small molecular weight agonists (and/or antagonists) of these interactions would thus likely have significant clinical importance. The data reported herein characterizes several such molecules in a number of rodent models.
Keywords: Tolerance, immunosuppression, inflammation, immunoglobulin superfamily
Medicinal Chemistry
Title: A Comparison of the Biological Properties of Small Molecular Weight Agonists and Antagonists of CD200:CD200R Interactions
Volume: 4 Issue: 6
Author(s): Reg Gorczynski, Ivo Boudakov and Ismat Khatri
Affiliation:
Keywords: Tolerance, immunosuppression, inflammation, immunoglobulin superfamily
Abstract: Our laboratory and others have documented in some detail the immunological consequences which follow from interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R (expressed predominantly on cells of myeloid and lymphoid origin). In particular, there is evidence that these interactions lead to immunosuppressive signals which modulate graft rejection responses; decrease the manifestations of arthritis in rodent models; diminish mast cell mediator release in models of allergic disease; and favour the growth of tumors in both mice and humans. The development of small molecular weight agonists (and/or antagonists) of these interactions would thus likely have significant clinical importance. The data reported herein characterizes several such molecules in a number of rodent models.
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Cite this article as:
Gorczynski Reg, Boudakov Ivo and Khatri Ismat, A Comparison of the Biological Properties of Small Molecular Weight Agonists and Antagonists of CD200:CD200R Interactions, Medicinal Chemistry 2008; 4 (6) . https://dx.doi.org/10.2174/157340608786241981
DOI https://dx.doi.org/10.2174/157340608786241981 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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