Abstract
Voltage-gated Calcium channels (VGCCs) play important roles in neurotransmitter release, excitationcontraction coupling, hormone secretion, and a variety of other physiological processes. Currently, there exist ion channel therapeutics for anxiety, epilepsy, hypertension, insomnia and pain. There is limited amount of study in this area despite their relevance to human disease and VGCCs remain considerably underexploited. The present review mainly focuses on calcium channel blockers (CCBs), especially for L-type channels and T-type channels, and therein lie some of the opportunities and advantages associated with VGCCs as drug targets.
Keywords: Calcium, Voltage gated channel, L-type channel, T-type channel, dihydropyridine
Mini-Reviews in Medicinal Chemistry
Title: Therapeutic Potential of Voltage Gated Calcium Channels
Volume: 8 Issue: 12
Author(s): C. Gopi Mohan and Tamanna Gandhi
Affiliation:
Keywords: Calcium, Voltage gated channel, L-type channel, T-type channel, dihydropyridine
Abstract: Voltage-gated Calcium channels (VGCCs) play important roles in neurotransmitter release, excitationcontraction coupling, hormone secretion, and a variety of other physiological processes. Currently, there exist ion channel therapeutics for anxiety, epilepsy, hypertension, insomnia and pain. There is limited amount of study in this area despite their relevance to human disease and VGCCs remain considerably underexploited. The present review mainly focuses on calcium channel blockers (CCBs), especially for L-type channels and T-type channels, and therein lie some of the opportunities and advantages associated with VGCCs as drug targets.
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Cite this article as:
Mohan Gopi C. and Gandhi Tamanna, Therapeutic Potential of Voltage Gated Calcium Channels, Mini-Reviews in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/138955708786141016
DOI https://dx.doi.org/10.2174/138955708786141016 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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