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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Chalcones and their Potential Role in Inflammation

Author(s): C. Kontogiorgis, M. Mantzanidou and D. Hadjipavlou-Litina

Volume 8, Issue 12, 2008

Page: [1224 - 1242] Pages: 19

DOI: 10.2174/138955708786141034

Price: $65

Abstract

Chalcones are a group of phenolic compounds which possess a wide variety of cytoprotective and modulatory functions. They have been shown to possess antioxidant, oxygen scavenging and anti-inflammatory properties in a variety of experimental systems and can trigger the intracellular cascade of protective pathways offering a promising stratagem for therapeutic applications. In this research we will review the anti-inflammatory effect of chalcone derivatives and new approaches.

Keywords: Natural/synthetic chalcones, inflammation, anti-inflammatories, antioxidants


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