Abstract
Caldesmon is a negative regulator of cell proliferation, migration, and metalloproteinase release. Caldesmon function is regulated by multiple kinases, targeting multiple phosphorylation sites. Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases.
Keywords: Actin, atherosclerosis, caldesmon, calmodulin, restenosis, vascular smooth muscle
Mini-Reviews in Medicinal Chemistry
Title: Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases
Volume: 8 Issue: 12
Author(s): Chi-Ming Hai
Affiliation:
Keywords: Actin, atherosclerosis, caldesmon, calmodulin, restenosis, vascular smooth muscle
Abstract: Caldesmon is a negative regulator of cell proliferation, migration, and metalloproteinase release. Caldesmon function is regulated by multiple kinases, targeting multiple phosphorylation sites. Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases.
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Cite this article as:
Hai Chi-Ming, Caldesmon as a Therapeutic Target for Proliferative Vascular Diseases, Mini-Reviews in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/138955708786140981
DOI https://dx.doi.org/10.2174/138955708786140981 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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