Abstract
Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5- bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.
Keywords: 7,11-Diarylspiro[5.5]undecane-1, 9-dione, synthesis, ultrasound irradiation, Michael condensation, phase-transfer catalysis
Letters in Organic Chemistry
Title: An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst
Volume: 5 Issue: 7
Author(s): Ji-Tai Li, Xin-Li Zhai, Zhi-Ping Lin and Xiao-Hui Zhang
Affiliation:
Keywords: 7,11-Diarylspiro[5.5]undecane-1, 9-dione, synthesis, ultrasound irradiation, Michael condensation, phase-transfer catalysis
Abstract: Improved synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione via double Michael condensation of 1,5- bisaryl-1,4-pentadien-3-one with cyclohexanone was carried out in 51-96% yields for 3-12 h in CH2Cl2-H2O in the presence of phase-transfer catalyst under ultrasound irradiation. In comparison with reported methods, the main advantages of the present procedure are shorter reaction time and higher yields.
Export Options
About this article
Cite this article as:
Li Ji-Tai, Zhai Xin-Li, Lin Zhi-Ping and Zhang Xiao-Hui, An Efficient Synthesis of 7,11-diarylspiro[5.5]undecane-1,9-dione by the Michael Condensation Under Ultrasound Irradiation in Aqueous and Organic Two Phase in the Presence of Phase-Transfer Catalyst, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982103
DOI https://dx.doi.org/10.2174/157017808785982103 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Is It Possible to Apply Secondary Stroke Prevention Guidelines to Very Old Populations?
Cardiovascular & Hematological Disorders-Drug Targets Classical Neurotransmitters and Neuropeptides Involved in Schizophrenia: How to Choose the Appropriate Antipsychotic Drug?
Current Drug Therapy Drug Treatment of Metabolic Syndrome
Current Clinical Pharmacology Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update
Current Drug Therapy Multidrug Transporters as Drug Targets
Current Drug Targets The Use of Human Albumin for the Treatment of Ascites in Patients with Liver Cirrhosis: Item of Safety, Facts, Controversies and Perspectives
Current Drug Safety Stress, Cardiovascular Diseases and Surgery-Induced Angiogenesis
Current Angiogenesis (Discontinued) Not Only a Clinical Nightmare: Amniotic Fluid Embolism in Court
Current Pharmaceutical Biotechnology Nimodipine Reappraised: An Old Drug With a Future
Current Neuropharmacology Adrenomedullin as a Potential Therapeutic Agent for Inflammatory Bowel Disease
Current Protein & Peptide Science Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Regulatory Requirements for Collection, Administration and Transfusion of Blood and Blood Products
Applied Clinical Research, Clinical Trials and Regulatory Affairs Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies
Current Drug Targets Cardiovascular Diseases in Pregnancy - A Brief Overview
Current Cardiology Reviews Pediatric Abdominal Trauma
Current Pediatric Reviews Approaches for Administering Chemotherapy in the Intensive Care Unit
Current Drug Safety Adrenoceptors: Non Conventional Target for Breast Cancer?
Current Medicinal Chemistry Importance of ABC Transporters in Drug Development
Current Pharmaceutical Design Vasopressin and Oxytocin in Control of the Cardiovascular System
Current Neuropharmacology Role of WNK Kinases in Blood Pressure Control
Current Hypertension Reviews