Abstract
p-Nitrobenzylphosphonic acid was obtained via a nucleophilic substitution of nitrobenzyl bromide with trimethyl phosphite as opposed to nitration of benzylphosphonic acid. This compound is a competitive inhibitor of alkaline phosphatase (KI ∼ 125 μM) and has potential to inhibit a wide range of other phosphatases including serine/threonine phosphatases and tyrosine phosphatases.
Keywords: Alkaline phosphatase, enzyme inhibition, nucleophilic substitution
Letters in Organic Chemistry
Title: A Novel Synthesis of p-Nitrobenzylphosphonic Acid and its Action on Alkaline Phosphatase
Volume: 5 Issue: 7
Author(s): James K. Hand, Amanda L. Stewart, Randy B. Sears, Trianna R. McCall and Catherine M. Davis- McGibony
Affiliation:
Keywords: Alkaline phosphatase, enzyme inhibition, nucleophilic substitution
Abstract: p-Nitrobenzylphosphonic acid was obtained via a nucleophilic substitution of nitrobenzyl bromide with trimethyl phosphite as opposed to nitration of benzylphosphonic acid. This compound is a competitive inhibitor of alkaline phosphatase (KI ∼ 125 μM) and has potential to inhibit a wide range of other phosphatases including serine/threonine phosphatases and tyrosine phosphatases.
Export Options
About this article
Cite this article as:
Hand K. James, Stewart L. Amanda, Sears B. Randy, McCall R. Trianna and Davis- McGibony M. Catherine, A Novel Synthesis of p-Nitrobenzylphosphonic Acid and its Action on Alkaline Phosphatase, Letters in Organic Chemistry 2008; 5 (7) . https://dx.doi.org/10.2174/157017808785982167
DOI https://dx.doi.org/10.2174/157017808785982167 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chromatographic Retention Parameters in Medicinal Chemistry and Molecular Pharmacology
Current Medicinal Chemistry Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?
Current Drug Targets EHDA Spraying: A Multi-Material Nano-Engineering Route
Current Pharmaceutical Design Kidney Diseases and Chemokines
Current Drug Targets Paving Roads for New Drugs in Oncology
Recent Patents on Anti-Cancer Drug Discovery A Comprehensive Review on Exosomes and Microvesicles as Epigenetic Factors
Current Stem Cell Research & Therapy PUFA for Human Health: Diet or Supplementation?
Current Pharmaceutical Design Antisense Oligonucleotide Drug Design
Current Pharmaceutical Design Bronchiolitis Care in the Hospital
Reviews on Recent Clinical Trials Allergen-specific Immunotherapy for Inhalant Allergens in Children
Current Pediatric Reviews Antinflammatory Effects of Allergen Immunotherapy
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Chemokines as Potential Therapeutic Targets in Atherosclerosis
Current Drug Targets Flavonoids on Allergy
Current Pharmaceutical Design Therapeutic Use of Heat Shock Protein 70
Recent Patents on DNA & Gene Sequences NK Cells and Asthma
Current Pharmaceutical Design Hypersensitivity Reactions from Excipients in Systemic Glucocorticoid Formulations
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Clinical Considerations in Developing Dendritic Cell Vaccine Based Immunotherapy Protocols in Cancer
Current Molecular Medicine Investigating the Associations between Mediterranean Diet, Physical Activity and Living Environment with Childhood Asthma using Path Analysis
Endocrine, Metabolic & Immune Disorders - Drug Targets Caring for HIV-Infected Patients in the ICU in The Highly Active Antiretroviral Therapy Era
Current HIV Research