96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Tiina      Heikkila; Leena      Peltonen; Saila      Taskinen; Timo      Laaksonen; Jouni      Hirvonen

Abstract

Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

Keywords: Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate

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Letters in Drug Design & Discovery

Title: 96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Volume: 5 Issue: 7

Author(s): Tiina Heikkila, Leena Peltonen, Saila Taskinen, Timo Laaksonen and Jouni Hirvonen

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Keywords: Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate

Abstract: Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

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Heikkila Tiina, Peltonen Leena, Taskinen Saila, Laaksonen Timo and Hirvonen Jouni, 96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility, Letters in Drug Design & Discovery 2008; 5 (7) . https://dx.doi.org/10.2174/157018008785909840