Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method

Sara   Zargar   Shoshtari; Jingyuan      Wen; Raid.   G.   Alany

Abstract

Applicability of HPLC based models for calculating partition coefficient (logP) of steroids was investigated. Retention time was used to calculate retention factor (logK), isocratic (CHIi) and gradient (CHIg) Chromatography Hydrophobicity Index. CHIi was shown to be an accurate logP predictor for selected steroids and as such offer an alternative to the shake flask method.

Keywords: Partition coefficient, Reversed phased liquid chromatography, Chromatographic Hydrophobicity Index (CHI), Lipophilicity

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Letters in Drug Design & Discovery

Title: Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method

Volume: 5 Issue: 6

Author(s): Sara Zargar Shoshtari, Jingyuan Wen and Raid. G. Alany

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Keywords: Partition coefficient, Reversed phased liquid chromatography, Chromatographic Hydrophobicity Index (CHI), Lipophilicity

Abstract: Applicability of HPLC based models for calculating partition coefficient (logP) of steroids was investigated. Retention time was used to calculate retention factor (logK), isocratic (CHIi) and gradient (CHIg) Chromatography Hydrophobicity Index. CHIi was shown to be an accurate logP predictor for selected steroids and as such offer an alternative to the shake flask method.

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Shoshtari Zargar Sara, Wen Jingyuan and Alany G. Raid., Octanol Water Partition Coefficient Determination for Model Steroids Using an HPLC Method, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777333