Abstract
A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.
Keywords: Chalcone, 2(3H)-Benzoxazolone, Mannich base, Cytotoxicity
Letters in Drug Design & Discovery
Title: New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone
Volume: 5 Issue: 6
Author(s): O. Petrov, Y. Ivanova, G. Momekov and V. Kalcheva
Affiliation:
Keywords: Chalcone, 2(3H)-Benzoxazolone, Mannich base, Cytotoxicity
Abstract: A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.
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Cite this article as:
Petrov O., Ivanova Y., Momekov G. and Kalcheva V., New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone, Letters in Drug Design & Discovery 2008; 5 (6) . https://dx.doi.org/10.2174/157018008785777342
DOI https://dx.doi.org/10.2174/157018008785777342 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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