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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Biochemical and Structural Investigations of Bothropstoxin-II, a Myotoxic Asp49 Phospholipase A2 from Bothrops jararacussu Venom

Author(s): Mario T. Murakami, Marco R. Lourenzoni, Emerson Z. Arruda, Marcelo A. Tomaz, Magno M. Vicoti, Jose R. B. Abrego, Paulo A. Melo and Raghuvir K. Arni

Volume 15, Issue 9, 2008

Page: [1002 - 1008] Pages: 7

DOI: 10.2174/092986608785849245

Price: $65

Abstract

Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.

Keywords: Phospholipases A2, suramin, pharmacological activities, structural studies

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