Abstract
Mastoparan, a toxic peptide from wasp venom, induces various biological functions including histamine release from rat peritoneal mast cells. Here we report that, for the activation of mast cells by mastoparan, at least two positively charged side chains are required on the hydrophilic side of the amphiphilic structure of the peptide. The present results are expected to be utilized for the bioinformatic and comprehensive identification of endogenous mast cell-stimulating cryptides.
Keywords: Mastoparan, exocytosis, peritoneal mast cells, β-hexosaminidase, lactate dehydrogenase, G protein
Protein & Peptide Letters
Title: Elucidation of Structural Requirements of Mastoparan for Mast Cell Activation- Toward the Comprehensive Prediction of Cryptides Acting on Mast Cells
Volume: 15 Issue: 9
Author(s): H. Mukai, Y. Suzuki, Y. Kiso and E. Munekata
Affiliation:
Keywords: Mastoparan, exocytosis, peritoneal mast cells, β-hexosaminidase, lactate dehydrogenase, G protein
Abstract: Mastoparan, a toxic peptide from wasp venom, induces various biological functions including histamine release from rat peritoneal mast cells. Here we report that, for the activation of mast cells by mastoparan, at least two positively charged side chains are required on the hydrophilic side of the amphiphilic structure of the peptide. The present results are expected to be utilized for the bioinformatic and comprehensive identification of endogenous mast cell-stimulating cryptides.
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Cite this article as:
Mukai H., Suzuki Y., Kiso Y. and Munekata E., Elucidation of Structural Requirements of Mastoparan for Mast Cell Activation- Toward the Comprehensive Prediction of Cryptides Acting on Mast Cells, Protein & Peptide Letters 2008; 15 (9) . https://dx.doi.org/10.2174/092986608785849362
DOI https://dx.doi.org/10.2174/092986608785849362 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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