Abstract
The development of a new generation of vaccines that can be produced rapidly at low costs and massadministered noninvasively by non-medical personnel is crucial for boosting vaccine coverage in response to an escalation in demand. The demonstration that topical application of bioengineered nonreplicating Escherichia coli particles overproducing pathogen-derived antigens can mobilize the immune repertoire toward beneficial immune protection against relevant pathogens holds promise for enabling mass-immunization without pain, fear and perceivable tissue damage. Moreover, this noninvasive regimen using E. coli epitopes as a natural adjuvant is in compliance with evolutionary medicine.
Keywords: Skin, stratum corneum, Escherichia coli, γ-irradiation, noninvasive vaccine, epicutaneous immunization
Infectious Disorders - Drug Targets
Title: Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine
Volume: 8 Issue: 3
Author(s): Jianfeng Zhang and De-chu C. Tang
Affiliation:
Keywords: Skin, stratum corneum, Escherichia coli, γ-irradiation, noninvasive vaccine, epicutaneous immunization
Abstract: The development of a new generation of vaccines that can be produced rapidly at low costs and massadministered noninvasively by non-medical personnel is crucial for boosting vaccine coverage in response to an escalation in demand. The demonstration that topical application of bioengineered nonreplicating Escherichia coli particles overproducing pathogen-derived antigens can mobilize the immune repertoire toward beneficial immune protection against relevant pathogens holds promise for enabling mass-immunization without pain, fear and perceivable tissue damage. Moreover, this noninvasive regimen using E. coli epitopes as a natural adjuvant is in compliance with evolutionary medicine.
Export Options
About this article
Cite this article as:
Zhang Jianfeng and Tang C. De-chu, Topical Application of Escherichia coli Particles Over-Producing Pathogen-Derived Antigens as a Simple Vaccination Modality in Compliance with Evolutionary Medicine, Infectious Disorders - Drug Targets 2008; 8 (3) . https://dx.doi.org/10.2174/1871526510808030189
DOI https://dx.doi.org/10.2174/1871526510808030189 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lifestyle Choices and Endothelial Function: Risk and Relevance
Current Vascular Pharmacology Pharmacological Modulation of p53 Function in Cancer Therapy
Current Signal Transduction Therapy Patent Selections
Recent Patents on Biotechnology Antiviral Compounds Based on Natural Astragalus polysaccharides (APS): Research and Foresight in the Strategies for Combating SARS-CoV-2 (COVID-19)
Mini-Reviews in Medicinal Chemistry Stem Cells in Cardiovascular Regeneration: From Preservation of Endogenous Repair to Future Cardiovascular Therapies
Current Pharmaceutical Design Is Combination Therapy of Atosiban and Nifedipine More Effective in Preterm Labor than Each Drug Alone? A Prospective Study
Current Women`s Health Reviews Gastrointestinal Bleeding Associated With Warfarin and Rivaroxaban Therapy in Atrial Fibrillation Cases with Concomitant Coagulopathy
Cardiovascular & Hematological Disorders-Drug Targets TRPV4 Agonists and Antagonists
Current Topics in Medicinal Chemistry Subtype Classification by Polymerase and Gag Genes of HIV-1 Iranian Sequences Registered in the NCBI GenBank
Current Proteomics Scorpion Toxin Polyptides as Therapeutic Agents: An Overview
Protein & Peptide Letters Protein C Inhibitor as an Anti-Disseminated Intravascular Coagulation Agent - Mechanism and Modification
Current Medicinal Chemistry - Cardiovascular & Hematological Agents EDITORIAL (Thematic Issue: Brain Gut Axis-New View)
Current Neuropharmacology Inactivation of Parathyroid Hormone: Perspectives of Drug Discovery to Combating Hyperparathyroidism
Current Molecular Pharmacology Emerging Risk Factors for Cerebrovascular Disease
Current Drug Targets Hydrogen Sulfide in Gastrointestinal and Liver Physiopathology
Inflammation & Allergy - Drug Targets (Discontinued) Signal Transduction in HIV Protein-Treated Astrocytes
Current Signal Transduction Therapy A Microextraction Liquid-Chromatographic Determination of Aristolochic Acid I in Urine, Flour, and Aristolochiaceae Fruit
Current Pharmaceutical Analysis MicroRNAs in Abdominal Aortic Aneurysm
Current Vascular Pharmacology Affinity Purification and Mass Spectrometry: An Attractive Choice to Investigate Protein-Protein Interactions in Plant Immunity
Current Proteomics Arundic Acid (ONO-2506) Ameliorates Delayed Ischemic Brain Damage by Preventing Astrocytic Overproduction of S100B
Current Drug Targets - CNS & Neurological Disorders