Synthesis of 2-Methyl N10-Substituted Acridones as Selective Inhibitors of Multidrug Resistance (MDR) Associated Protein in Cancer Cells

Title: Synthesis of 2-Methyl N10-Substituted Acridones as Selective Inhibitors of Multidrug Resistance (MDR) Associated Protein in Cancer Cells

Volume: 4 Issue: 5

Author(s): Y. C. Mayur, Osman Ahmad, V. V.S. Rajendra Prasad, M. N. Purohit, N. Srinivasulu and S. M. Shanta Kumar

Affiliation:

Keywords: Acridones, anti-cancer, P-glycoprotein (P-gp), multidrug resistance (MDR)

Abstract: A series of N10-substituted-2-methyl acridone derivatives are synthesized and are examined for its ability to reverse P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in breast cancer cell lines MCF-7 and MCF-7/Adr. The structural requirement of in-vitro anti-cancer and reversal of drug resistance are studied. The results showed that compound 16 with four carbon spacer exhibited promising in-vitro anti-cancer and reversal of drug resistance in comparison to the other analogues.

Cite this article as:

Mayur C. Y., Ahmad Osman, Rajendra Prasad V.S. V., Purohit N. M., Srinivasulu N. and Shanta Kumar M. S., Synthesis of 2-Methyl N10-Substituted Acridones as Selective Inhibitors of Multidrug Resistance (MDR) Associated Protein in Cancer Cells, Medicinal Chemistry 2008; 4 (5) . https://dx.doi.org/10.2174/157340608785700180