Abstract
This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
Keywords: Computer aided drug design, molecular modeling, structure-activity relationship, hormones, drug design, structure, QSAR, phytoestrogens
Mini-Reviews in Medicinal Chemistry
Title: Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity
Volume: 8 Issue: 9
Author(s): S. Agatonovic-Kustrin and J. V. Turner
Affiliation:
Keywords: Computer aided drug design, molecular modeling, structure-activity relationship, hormones, drug design, structure, QSAR, phytoestrogens
Abstract: This review will discuss the structural determinants and requirements necessary for estrogen receptors alpha and beta selectivity and ligand-receptor binding affinity. In addition, strategies likely to result in the development of a pharmacophore model that account for the differences in estrogenic effects between different ligands will be discussed.
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Cite this article as:
Agatonovic-Kustrin S. and Turner V. J., Molecular Structural Characteristics of Estrogen Receptor Modulators as Determinants of Estrogen Receptor Selectivity, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132747
DOI https://dx.doi.org/10.2174/138955708785132747 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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