Abstract
Recently, the serotonin 5-HT6 receptor has been identified as a drug target for attenuating cognitive deficits associated with Alzheimers disease (AD). Additionally, this receptor may also play a role in schizophrenia, anxiety and obesity. Reports in the literature suggest that the production of selective antagonists for the 5-HT6 receptor has increased during the last 10 years, with some compounds currently in clinical trials for the treatment of AD. In this review, we will address the rationale for using 5-HT6 receptor antagonists in AD, as well as report on current advances in the understanding of the structure-activity relationships required to synthesize 5-HT6 receptor antagonists.
Keywords: QSAR, G-coupled protein receptor, GCPR, tryptamine, arylsulfonyl, multifunctional, dementia
Current Topics in Medicinal Chemistry
Title: Serotonin 5-HT6 Receptor Antagonists for the Treatment of Alzheimers Disease
Volume: 8 Issue: 12
Author(s): Werner J. Geldenhuys and Cornelis J. Van der Schyf
Affiliation:
Keywords: QSAR, G-coupled protein receptor, GCPR, tryptamine, arylsulfonyl, multifunctional, dementia
Abstract: Recently, the serotonin 5-HT6 receptor has been identified as a drug target for attenuating cognitive deficits associated with Alzheimers disease (AD). Additionally, this receptor may also play a role in schizophrenia, anxiety and obesity. Reports in the literature suggest that the production of selective antagonists for the 5-HT6 receptor has increased during the last 10 years, with some compounds currently in clinical trials for the treatment of AD. In this review, we will address the rationale for using 5-HT6 receptor antagonists in AD, as well as report on current advances in the understanding of the structure-activity relationships required to synthesize 5-HT6 receptor antagonists.
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Cite this article as:
Geldenhuys J. Werner and Van der Schyf J. Cornelis, Serotonin 5-HT6 Receptor Antagonists for the Treatment of Alzheimers Disease, Current Topics in Medicinal Chemistry 2008; 8 (12) . https://dx.doi.org/10.2174/156802608785161420
DOI https://dx.doi.org/10.2174/156802608785161420 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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