Abstract
Albumin is a complex molecule that is a principal transporter of plasma fatty acids and binds to majority of the drugs ingested. Albumin traps oxygen radicals and has anti-oxidant actions that exceed that of vitamin E. Vascular endothelial cells express specific binding sites for albumin that may aid in its ability to prevent endothelial cell apoptosis. Albumin regulates the enzyme pyruvate dehydrogenase in astrocytes and thus helps in the flux of glucose and lactate. Thus, albumin could limit ischemia-induced neuronal damage. Recent studies showed that intravenous albumin administration improved neurological function by reducing infarction volume and cerebral edema. In addition, albumin seems to be useful in the treatment of in those who are critically ill due to due to medical and surgical conditions, and sepsis. The cytoprotective action of albumin is due to an increase in the formation of protectins from docosahexaenoic acid (DHA) and possibly, other polyunsaturated fatty acids.
Keywords: Sepsis, critical illness, albumin, docosahexaenoic acid, polyunsaturated fatty acids, lipoxins, resolvins, neuroprotectin D1, stroke, neuroprotection
Current Nutrition & Food Science
Title: Albumin Infusion Therapy in Stroke, Sepsis and the Critically Ill
Volume: 4 Issue: 3
Author(s): Undurti N. Das
Affiliation:
Keywords: Sepsis, critical illness, albumin, docosahexaenoic acid, polyunsaturated fatty acids, lipoxins, resolvins, neuroprotectin D1, stroke, neuroprotection
Abstract: Albumin is a complex molecule that is a principal transporter of plasma fatty acids and binds to majority of the drugs ingested. Albumin traps oxygen radicals and has anti-oxidant actions that exceed that of vitamin E. Vascular endothelial cells express specific binding sites for albumin that may aid in its ability to prevent endothelial cell apoptosis. Albumin regulates the enzyme pyruvate dehydrogenase in astrocytes and thus helps in the flux of glucose and lactate. Thus, albumin could limit ischemia-induced neuronal damage. Recent studies showed that intravenous albumin administration improved neurological function by reducing infarction volume and cerebral edema. In addition, albumin seems to be useful in the treatment of in those who are critically ill due to due to medical and surgical conditions, and sepsis. The cytoprotective action of albumin is due to an increase in the formation of protectins from docosahexaenoic acid (DHA) and possibly, other polyunsaturated fatty acids.
Export Options
About this article
Cite this article as:
Das N. Undurti, Albumin Infusion Therapy in Stroke, Sepsis and the Critically Ill, Current Nutrition & Food Science 2008; 4 (3) . https://dx.doi.org/10.2174/157340108785133329
DOI https://dx.doi.org/10.2174/157340108785133329 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
Call for Papers in Thematic Issues
Functional Foods in Human Health and Beyond
Foods are important source of nutrients including carbohydrates, proteins, lipids and other minerals. Furthermore, the functional foods are those agents that have additional components that are essential supports to the body in terms of antioxidant and pharmacologically active agents. The predominant functional foods are of plant in origin, whereas some ...read more
Harnessing Bioactive Compounds from Food Waste: Sustainable Extraction Strategies and Health Applications
Food waste presents a significant challenge across the postharvest cycle, from agricultural production to distribution. However, within this waste lies a treasure trove of bioactive chemicals that hold immense potential for nutraceuticals, functional foods, and postharvest additives, including antimicrobials. Various extraction methods, such as solvent extraction (SE), supercritical fluid extraction ...read more
Natural Bioactive Compounds Derivatives in Nutraceutical and Food Science
In the last years, plants have been widely used for their numerous properties and now there is growing interest in the study of classes of compounds obtained from plant species or derived from them. The importance of these natural compounds lies in their important therapeutic purposes, and in their capability ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Emerging Antimicrobial Applications of Nitric Oxide (NO) and NO-Releasing Materials
Anti-Infective Agents in Medicinal Chemistry Hyperglycemia and Perioperative Glucose Management
Current Pharmaceutical Design Scientific and Clinical Challenges in Sepsis
Current Pharmaceutical Design Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress
Current Drug Metabolism High Blood Pressure and the Risk of Stroke
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Doxorubicin: The Good, the Bad and the Ugly Effect
Current Medicinal Chemistry The Validity of Chemical Analytical Methods by the Example of the Heparin Product Recall
Current Pharmaceutical Analysis Inflammatory Mediators and the Failing Heart: A Translational Approach
Current Molecular Medicine Blood Pressure as a Therapeutic Target in Stroke
Current Topics in Medicinal Chemistry Evaluation of Clinical Efficacy of Fasudil for the Treatment of Pulmonary Arterial Hypertension
Recent Patents on Cardiovascular Drug Discovery Metformin Beyond Diabetes: New Life for an Old Drug
Current Diabetes Reviews Neuroprotective Role of Agmatine in Neurological Diseases
Current Neuropharmacology Adjunctive Therapies in Severe Pneumonia in Critical Care Patients
Infectious Disorders - Drug Targets Dopexamine After Heart Surgery: An Uncommonly Used, Though Useful Inotropic Agent
Recent Patents on Cardiovascular Drug Discovery Editorial: Perioperative Pharmacological Management: From Prescription Medications to Dietary Supplements
Current Clinical Pharmacology A2A Adenosine Receptor and its Modulators: Overview on a Druggable GPCR and on Structure-Activity Relationship Analysis and Binding Requirements of Agonists and Antagonists
Current Pharmaceutical Design Beta-Blockers and Nitrates: Pharmacotherapy and Indications
Cardiovascular & Hematological Agents in Medicinal Chemistry Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Adrenomedullin Expression in Alzheimer's Brain
Current Alzheimer Research Cardiovascular Therapeutics Targets on the NO–sGC–cGMP Signaling Pathway: A Critical Overview
Current Drug Targets