Abstract
There is increasing evidence that diabetes mellitus and Alzheimers disease occur more often than by chance. Recently, we proposed that increase in the activity of the enzyme butyrylcholinesterase could be a common link between these two conditions. Acetylcholine is an anti-inflammatory molecule. Butyrylcholinesterase by inactivating acetylcholine may enhance inflammation and induce decline in cognitive function. In the present study, it was noted that streptozotocininduced diabetic animals showed dyslipidemia, increase in plasma lipid peroxides, decrease in circulating plasma superoxide dismutase activity, decline in cognitive function as assessed by the Morris water maze method, and a significant increase in serum butyrylcholinesterase activity. These results suggest that increased plasma and, possibly, tissue concentrations of butyrylcholinesterase lead to decrease in acetylcholine levels, an anti-inflammatory molecule, which may trigger low-grade systemic inflammation in diabetes mellitus and Alzheimers disease that could account for decline in cognitive function.
Keywords: Diabetes mellitus, Alzheimer's disease, hyperlipidemia, hyperglycemia, anti-oxidants, lipid peroxidation, cognitive function, butyrylcholinesterase, acetylcholine, inflammation
Current Nutrition & Food Science
Title: Enhanced Butyrylcholinesterase Activity may be the Common Link in Triggering Low-Grade Systemic Inflammation and Decrease in Cognitive Function in Diabetes Mellitus and Alzheimers disease
Volume: 4 Issue: 3
Author(s): Allam A. Rao, C. Siva Reddy, G. R. Sridhar, A. Annapurna, T. Hanuman, M. Prameela, K. Suresh, S. Prasannalaxmi and Undurti N. Das
Affiliation:
Keywords: Diabetes mellitus, Alzheimer's disease, hyperlipidemia, hyperglycemia, anti-oxidants, lipid peroxidation, cognitive function, butyrylcholinesterase, acetylcholine, inflammation
Abstract: There is increasing evidence that diabetes mellitus and Alzheimers disease occur more often than by chance. Recently, we proposed that increase in the activity of the enzyme butyrylcholinesterase could be a common link between these two conditions. Acetylcholine is an anti-inflammatory molecule. Butyrylcholinesterase by inactivating acetylcholine may enhance inflammation and induce decline in cognitive function. In the present study, it was noted that streptozotocininduced diabetic animals showed dyslipidemia, increase in plasma lipid peroxides, decrease in circulating plasma superoxide dismutase activity, decline in cognitive function as assessed by the Morris water maze method, and a significant increase in serum butyrylcholinesterase activity. These results suggest that increased plasma and, possibly, tissue concentrations of butyrylcholinesterase lead to decrease in acetylcholine levels, an anti-inflammatory molecule, which may trigger low-grade systemic inflammation in diabetes mellitus and Alzheimers disease that could account for decline in cognitive function.
Export Options
About this article
Cite this article as:
Rao A. Allam, Reddy Siva C., Sridhar R. G., Annapurna A., Hanuman T., Prameela M., Suresh K., Prasannalaxmi S. and Das N. Undurti, Enhanced Butyrylcholinesterase Activity may be the Common Link in Triggering Low-Grade Systemic Inflammation and Decrease in Cognitive Function in Diabetes Mellitus and Alzheimers disease, Current Nutrition & Food Science 2008; 4 (3) . https://dx.doi.org/10.2174/157340108785133310
DOI https://dx.doi.org/10.2174/157340108785133310 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
Call for Papers in Thematic Issues
Functional Foods in Human Health and Beyond
Foods are important source of nutrients including carbohydrates, proteins, lipids and other minerals. Furthermore, the functional foods are those agents that have additional components that are essential supports to the body in terms of antioxidant and pharmacologically active agents. The predominant functional foods are of plant in origin, whereas some ...read more
Harnessing Bioactive Compounds from Food Waste: Sustainable Extraction Strategies and Health Applications
Food waste presents a significant challenge across the postharvest cycle, from agricultural production to distribution. However, within this waste lies a treasure trove of bioactive chemicals that hold immense potential for nutraceuticals, functional foods, and postharvest additives, including antimicrobials. Various extraction methods, such as solvent extraction (SE), supercritical fluid extraction ...read more
Natural Bioactive Compounds Derivatives in Nutraceutical and Food Science
In the last years, plants have been widely used for their numerous properties and now there is growing interest in the study of classes of compounds obtained from plant species or derived from them. The importance of these natural compounds lies in their important therapeutic purposes, and in their capability ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Possible Involvement of Angiogenesis in Chronic Liver Diseases: Interaction Among Renin-Angiotensin-Aldosterone System, Insulin Resistance and Oxidative Stress
Current Medicinal Chemistry Multiple Defects in Energy Metabolism in Alzheimers Disease
Current Drug Targets Prevention of Sudden Cardiac Death in Hemodialysis Patients
Cardiovascular & Hematological Disorders-Drug Targets Patent Selections
Recent Patents on Food, Nutrition & Agriculture Diabetic Retinopathy and Angiogenesis
Current Diabetes Reviews Nutritional and therapeutic approaches to modulate NADPH oxidase-derived ROS signaling in platelets.
Current Pharmaceutical Design Frequency Domain and Entropy Analysis of Fetal Heart Rate: Appealing Tools for Fetal Surveillance and Pharmacodynamic Assessment of Drugs
Cardiovascular & Hematological Disorders-Drug Targets Optic Nerve and Cerebral Edema in the Course of Diabetic Ketoacidosis
Current Neuropharmacology Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease
Current Neurovascular Research The Complications of Bariatric Surgery Patients with Type 2 Diabetes in the World: A Systematic Review and Meta-Analysis
Current Diabetes Reviews Role of AGEs-RAGE System in Cardiovascular Disease
Current Pharmaceutical Design Targets of Anti-glucocorticoid Therapy for Stress-related Diseases
Recent Patents on CNS Drug Discovery (Discontinued) From Diabetes to Metabolic Syndrome: A View Point on An Evolving Concept
Current Pharmaceutical Design Targeting Metabolic Enzymes in Cancer – Clinical Trials Update
Current Enzyme Inhibition The Clinical Spectrum of Nephrogenic Systemic Fibrosis
Current Rheumatology Reviews Effects of Fatty Acids and Glycation on Drug Interactions with Human Serum Albumin
Current Metabolomics Intratubular Renin-Angiotensin System in Hypertension
Current Hypertension Reviews Wild Mice As Bountiful Resources of Novel Genetic Variants for Quantitative Traits
Current Genomics Pharmacogenetics Strategies: From Candidate Genes to Whole-Genome Association Analysis. Exploratory or Confirmatory Studies?
Current Pharmacogenomics and Personalized Medicine Inflammatory Mechanisms and Redox Status in Periodontal and Cardiometabolic Diseases: Effects of Adjunctive Nutritional Antioxidants and Statins
Infectious Disorders - Drug Targets