Abstract
Quantitative structure-activity relationship studies have been made on some calcium channel blockers (CCBs) that include the most widely studied class of 1,4-dihydropyridines and two new classes of CCBs, namely benzazepinone analogs and quinolizidinyl derivatives. In the case of 1,4-dihydropyridines some simple correlations have been found as compared to those reported in several earlier studies and in the other two classes it could be shown that the electronic parameters and the bulk of the molecules may be important for the activity of the compounds.
Letters in Drug Design & Discovery
Title: QSAR Studies on some Calcium Channel Blockers
Volume: 5 Issue: 5
Author(s): Mallari A. Naik, V. S.A. Kumar Satuluri and S. P. Gupta
Affiliation:
Abstract: Quantitative structure-activity relationship studies have been made on some calcium channel blockers (CCBs) that include the most widely studied class of 1,4-dihydropyridines and two new classes of CCBs, namely benzazepinone analogs and quinolizidinyl derivatives. In the case of 1,4-dihydropyridines some simple correlations have been found as compared to those reported in several earlier studies and in the other two classes it could be shown that the electronic parameters and the bulk of the molecules may be important for the activity of the compounds.
Export Options
About this article
Cite this article as:
Naik A. Mallari, Kumar Satuluri S.A. V. and Gupta P. S., QSAR Studies on some Calcium Channel Blockers, Letters in Drug Design & Discovery 2008; 5 (5) . https://dx.doi.org/10.2174/157018008784912090
DOI https://dx.doi.org/10.2174/157018008784912090 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
CCL2-CCR2 Signaling in Disease Pathogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets Effect of Dietary Supplementation of Black Seed (N. Sativa L.) on Lipid Profile of Patients Suffering from Diabetes
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Metabolic Drug Interactions Between Antidepressants and Anticancer Drugs: Focus on Selective Serotonin Reuptake Inhibitors and Hypericum Extract
Current Drug Metabolism Cannabis sativa L. Constituents and Their Role in Neuroinflammation
Current Bioactive Compounds Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence
Current Neuropharmacology Structural Activity Relationship and Importance of Benzothiazole Derivatives in Medicinal Chemistry: A Comprehensive Review
Mini-Reviews in Organic Chemistry Native Proteins in Organic Chemistry. Recent Achievements in the use of non Hydrolytic Enzymes for the Synthesis of Pharmaceuticals
Current Organic Chemistry Immunoproteasome in Cancer and Neuropathologies: A New Therapeutic Target?
Current Pharmaceutical Design Raf Inhibitors as Therapeutic Agents Against Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets
Current Protein & Peptide Science Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review
Recent Patents on Anti-Cancer Drug Discovery Screen-Printed Biosensors in Drug Analysis
Current Pharmaceutical Analysis Synthesis and Structure-Activity Relationship on Anticonvulsant Aryl Semicarbazones
Medicinal Chemistry Comparative Anatomy, Physiology and In Vitro Models of the Blood-Brain and Blood-Retina Barrier
Current Medicinal Chemistry - Central Nervous System Agents Neuroprotection and Hypothermia in Infants and Children
Current Drug Targets Anxioselective Compounds Acting at the GABAA Receptor Benzodiazepine Binding Site
Current Drug Targets - CNS & Neurological Disorders 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules
Mini-Reviews in Medicinal Chemistry High Temperature Unfolding Simulations of a Single-stranded DNA i-Motif
Current Physical Chemistry Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I
Current Neuropharmacology The Role of Peripheral Benzodiazepine Receptors (PBRs) in CNS Pathophysiology
Current Medicinal Chemistry