Abstract
Disturbances of endothelin production or clearance contribute to the pathophysiology of several cardiovascular diseases including Chagas disease cardiomyopathy caused by the protozoan Trypanosoma cruzi. In rats, endothelins contribute to control the acute phase, probably by stimulating nitric oxide production. We point out the necessity for new studies to better evaluate high levels of endothelin in the course of other infectious diseases, for which only its detrimental effects have been emphasized.
Keywords: Chagas Disease, cardiomyopathy, cytokines, chemokines, nitric oxide, endothelins, endothelial dysfunction, infectious disease
Mini-Reviews in Medicinal Chemistry
Title: Endothelins Role in the Control of the Acute Phase of Trypanosoma cruzi Infection
Volume: 8 Issue: 8
Author(s): Conceicao R.S. Machado and Elizabeth R.S. Camargos
Affiliation:
Keywords: Chagas Disease, cardiomyopathy, cytokines, chemokines, nitric oxide, endothelins, endothelial dysfunction, infectious disease
Abstract: Disturbances of endothelin production or clearance contribute to the pathophysiology of several cardiovascular diseases including Chagas disease cardiomyopathy caused by the protozoan Trypanosoma cruzi. In rats, endothelins contribute to control the acute phase, probably by stimulating nitric oxide production. We point out the necessity for new studies to better evaluate high levels of endothelin in the course of other infectious diseases, for which only its detrimental effects have been emphasized.
Export Options
About this article
Cite this article as:
Machado R.S. Conceicao and Camargos R.S. Elizabeth, Endothelins Role in the Control of the Acute Phase of Trypanosoma cruzi Infection, Mini-Reviews in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/138955708784912184
DOI https://dx.doi.org/10.2174/138955708784912184 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Pathology Induced by Highly Active Antiretroviral Therapy Against Human Immunodeficiency Virus: an Update
Current Medicinal Chemistry Non-glycemic Adverse Effects of Insulin
Current Diabetes Reviews Modulators of Inhibitor of Growth (ING) Family Expression in Development and Disease
Current Drug Targets Expression and Function of MicroRNAs in Heart Disease
Current Drug Targets Directions for Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cells in Different Neurodegenerative and Cardiovascular Diseases: Current Status and Future Perspectives
Current Stem Cell Research & Therapy Natriuretic Peptide Testing in Primary Care
Current Cardiology Reviews Association Between Intra-Hospital Uncontrolled Glycemia and Health Outcomes in Patients with Diabetes: A Systematic Review of Observational Studies
Current Diabetes Reviews Biologics and the Cardiovascular System: A Double-Edged Sword
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Spatial QRS-T Angle: Implications in Clinical Practice
Current Cardiology Reviews Gene Clusters, Molecular Evolution and Disease: A Speculation
Current Genomics AMI and Anabolic-Androgenic Steroids: Case Report with Systematic Review
Current Cardiology Reviews Free Fatty Acids: Circulating Contributors of Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry Flavonoids as Potential Therapeutic Agents for the Management of Diabetic Neuropathy
Current Pharmaceutical Design Targeting Myocardial Metabolism for the Treatment of Stable Angina
Current Pharmaceutical Design The Pattern of Calculated Inflammation Ratios as Prognostic Values in Patients with Colorectal Cancer
Combinatorial Chemistry & High Throughput Screening Polyamines and Related Nitrogen Compounds in the Chemotherapy of Neglected Diseases Caused by Kinetoplastids
Current Topics in Medicinal Chemistry GDF 15 - A Novel Biomarker in the Offing for Heart Failure
Current Cardiology Reviews ACE Inhibition Prevents Diastolic Ca2+ Overload and Loss of Myofilament Ca2+ Sensitivity after Myocardial Infarction
Current Molecular Medicine Patent Selections :
Recent Patents on Cardiovascular Drug Discovery Bayes Syndrome and Imaging Techniques
Current Cardiology Reviews