Abstract
Numerous studies implicate the prolyl peptidase, fibroblast activation protein (FAP) in tumorigenesis; however, FAP-selective inhibitors have not yet been developed to fully validate FAP as a therapeutic target. Herein, we review recent efforts aimed at validating and inhibiting FAP for cancer therapy and highlight future directions for successful targeting of this prolyl peptidase.
Keywords: FAP, DPP4, dipeptidyl peptidase, prolyl peptidase, inhibitor, cancer
Mini-Reviews in Medicinal Chemistry
Title: On The Edge of Validation – Cancer Protease Fibroblast Activation Protein
Volume: 8 Issue: 7
Author(s): Beni B. Wolf, Clifford Quan, Thuy Tran, Christian Wiesmann and Daniel Sutherlin
Affiliation:
Keywords: FAP, DPP4, dipeptidyl peptidase, prolyl peptidase, inhibitor, cancer
Abstract: Numerous studies implicate the prolyl peptidase, fibroblast activation protein (FAP) in tumorigenesis; however, FAP-selective inhibitors have not yet been developed to fully validate FAP as a therapeutic target. Herein, we review recent efforts aimed at validating and inhibiting FAP for cancer therapy and highlight future directions for successful targeting of this prolyl peptidase.
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Cite this article as:
Wolf B. Beni, Quan Clifford, Tran Thuy, Wiesmann Christian and Sutherlin Daniel, On The Edge of Validation – Cancer Protease Fibroblast Activation Protein, Mini-Reviews in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/138955708784567449
DOI https://dx.doi.org/10.2174/138955708784567449 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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