Abstract
Glucocorticoid action is linked to the development of obesity and insulin resistance. Inhibition of 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a strategy to suppress glucocorticoid action in a tissue-specific manner. A large variety of 11β-HSD1 inhibitor classes are under investigation by the pharmaceutical industry to treat type 2 diabetes and obesity.
Keywords: 11β-hydroxysteroid dehydrogenase, glucocorticoid receptor, cortisol, ex vivo activity, insulin resistance, Cushing's syndrome
Mini-Reviews in Medicinal Chemistry
Title: Development of 11β -HSD1 Inhibitors for the Treatment of Type 2 Diabetes
Volume: 8 Issue: 7
Author(s): Clarence Hale and Minghan Wang
Affiliation:
Keywords: 11β-hydroxysteroid dehydrogenase, glucocorticoid receptor, cortisol, ex vivo activity, insulin resistance, Cushing's syndrome
Abstract: Glucocorticoid action is linked to the development of obesity and insulin resistance. Inhibition of 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a strategy to suppress glucocorticoid action in a tissue-specific manner. A large variety of 11β-HSD1 inhibitor classes are under investigation by the pharmaceutical industry to treat type 2 diabetes and obesity.
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Cite this article as:
Hale Clarence and Wang Minghan, Development of 11β -HSD1 Inhibitors for the Treatment of Type 2 Diabetes, Mini-Reviews in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/138955708784567421
DOI https://dx.doi.org/10.2174/138955708784567421 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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