Abstract
Endothelial Lipase (EL) is a newly identified member of the triacylglycerol lipase family. Recent studies suggested that EL may be an important determinant of HDL-metabolism and inflammation acting at the level of the vessel wall. The aim of this review is to summarize important facts derived from experimental approaches and from epidemiologic human studies to provide a comprehensive view on the role of EL in inflammation and atherogenesis as well as target for potential pharmaceutical interventions.
Keywords: HDL metabolism, atherosclerosis, inflammation
Mini-Reviews in Medicinal Chemistry
Title: Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk
Volume: 8 Issue: 6
Author(s): Pascual DeSantis, Trey Coleman, Stephan Schiekofer, Peter P. Nawroth, Paul Schlimmer and Jochen G. Schneider
Affiliation:
Keywords: HDL metabolism, atherosclerosis, inflammation
Abstract: Endothelial Lipase (EL) is a newly identified member of the triacylglycerol lipase family. Recent studies suggested that EL may be an important determinant of HDL-metabolism and inflammation acting at the level of the vessel wall. The aim of this review is to summarize important facts derived from experimental approaches and from epidemiologic human studies to provide a comprehensive view on the role of EL in inflammation and atherogenesis as well as target for potential pharmaceutical interventions.
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Cite this article as:
DeSantis Pascual, Coleman Trey, Schiekofer Stephan, Nawroth P. Peter, Schlimmer Paul and Schneider G. Jochen, Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk, Mini-Reviews in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/138955708784534427
DOI https://dx.doi.org/10.2174/138955708784534427 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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