Abstract
Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.
Keywords: Rho GTPases, cancer, isoprenylation, statins, chemotherapy
Mini-Reviews in Medicinal Chemistry
Title: Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy
Volume: 8 Issue: 6
Author(s): Chiara Riganti, Elisabetta Aldieri, Sophie Doublier, Amalia Bosia and Dario Ghigo
Affiliation:
Keywords: Rho GTPases, cancer, isoprenylation, statins, chemotherapy
Abstract: Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.
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Cite this article as:
Riganti Chiara, Aldieri Elisabetta, Doublier Sophie, Bosia Amalia and Ghigo Dario, Statins-Mediated Inhibition of Rho GTPases as a Potential Tool in Anti-Tumor Therapy, Mini-Reviews in Medicinal Chemistry 2008; 8 (6) . https://dx.doi.org/10.2174/138955708784534436
DOI https://dx.doi.org/10.2174/138955708784534436 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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