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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer

Author(s): Yu Li, Hui Bin Zhang, Wen Long Huang, Xia Zhen and Yun Man Li

Volume 5, Issue 4, 2008

Page: [303 - 306] Pages: 4

DOI: 10.2174/157018008784619834

Price: $65

Abstract

A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N – cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.

Keywords: Tetrahydroisoquinoline, N, , cyanoguanyl, Synthesis, MDR, Modulator, P-glycoprotein

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