Abstract
A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N – cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.
Keywords: Tetrahydroisoquinoline, N, –, cyanoguanyl, Synthesis, MDR, Modulator, P-glycoprotein
Letters in Drug Design & Discovery
Title: Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer
Volume: 5 Issue: 4
Author(s): Yu Li, Hui Bin Zhang, Wen Long Huang, Xia Zhen and Yun Man Li
Affiliation:
Keywords: Tetrahydroisoquinoline, N, –, cyanoguanyl, Synthesis, MDR, Modulator, P-glycoprotein
Abstract: A series of novel tetrahydroisoquinoline derivatives (7a-b and 8a-j) were synthesized by using N – cyanoguanyl as a spacer, and their multidrug resistance reversal activities against K562/A02 cell line in vitro were evaluated by MTT method. It was found that 7a and 8b showed more potent multidrug resistance reversal activities than verapamil.
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Cite this article as:
Li Yu, Zhang Bin Hui, Huang Long Wen, Zhen Xia and Li Man Yun, Tetrahydroisoquinoline-Related Modulators of Multidrug Resistance in Cancer, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619834
DOI https://dx.doi.org/10.2174/157018008784619834 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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