Abstract
Effects of carbohydrate derivatives, synthesized exploring D-Glucose as starting material were studied in rat jejunum and tested in the muscarinic neurotransmission. The compounds shifted rightward and reduced maximum effect of curves for ACh. In KCl curves, they produced relaxing effects. Based on these experiments we suggest that these compounds act as non-competitive antagonists.
Keywords: Carbohydrates, Cholinergic neurotransmission, Muscarinic receptor, Atropine
Letters in Drug Design & Discovery
Title: Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor
Volume: 5 Issue: 4
Author(s): David R. da Rocha, Vitor F. Ferreira, Lucia Garcez-do-Carmo and Wilson C. Santos
Affiliation:
Keywords: Carbohydrates, Cholinergic neurotransmission, Muscarinic receptor, Atropine
Abstract: Effects of carbohydrate derivatives, synthesized exploring D-Glucose as starting material were studied in rat jejunum and tested in the muscarinic neurotransmission. The compounds shifted rightward and reduced maximum effect of curves for ACh. In KCl curves, they produced relaxing effects. Based on these experiments we suggest that these compounds act as non-competitive antagonists.
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Cite this article as:
da Rocha R. David, Ferreira F. Vitor, Garcez-do-Carmo Lucia and Santos C. Wilson, Design and Synthesis of Carbohydrate Derivatives for Antagonistic Activity at Muscarinic Receptor, Letters in Drug Design & Discovery 2008; 5 (4) . https://dx.doi.org/10.2174/157018008784619870
DOI https://dx.doi.org/10.2174/157018008784619870 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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