Abstract
Neonatal diabetes mellitus (NDM) is a rare cause of hyperglycemia in the neonatal period. We encountered a patient with neonatal diabetes mellitus and exocrine pancreatic insufficiency secondary to a homozygous insulin promoter factor-1 (IPF1) mutation. We sought to review the available literature regarding current etiologies and therapeutic options available to patients with NDM. Identification of genetic mutations and further investigation of neonatal diabetes mellitus has allowed for improvement in patient care and a better understanding of the etiology of neonatal diabetes mellitus. Given the rarity of the condition, the neonatologist, pediatrician and family practitioner must be aware of these changes in order to organize and facilitate appropriate care.
Keywords: Neonatal diabetes mellitus, IPF-1, pancreatic agenesis, hyperglycemia
Current Pediatric Reviews
Title: Neonatal Diabetes: Applying Molecular Biology to Patient Care
Volume: 4 Issue: 2
Author(s): Rebecca Vartanian and Steven M. Donn
Affiliation:
Keywords: Neonatal diabetes mellitus, IPF-1, pancreatic agenesis, hyperglycemia
Abstract: Neonatal diabetes mellitus (NDM) is a rare cause of hyperglycemia in the neonatal period. We encountered a patient with neonatal diabetes mellitus and exocrine pancreatic insufficiency secondary to a homozygous insulin promoter factor-1 (IPF1) mutation. We sought to review the available literature regarding current etiologies and therapeutic options available to patients with NDM. Identification of genetic mutations and further investigation of neonatal diabetes mellitus has allowed for improvement in patient care and a better understanding of the etiology of neonatal diabetes mellitus. Given the rarity of the condition, the neonatologist, pediatrician and family practitioner must be aware of these changes in order to organize and facilitate appropriate care.
Export Options
About this article
Cite this article as:
Vartanian Rebecca and Donn M. Steven, Neonatal Diabetes: Applying Molecular Biology to Patient Care, Current Pediatric Reviews 2008; 4 (2) . https://dx.doi.org/10.2174/157339608784462016
DOI https://dx.doi.org/10.2174/157339608784462016 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Amylin Replacement With Pramlintide as an Adjunct to Insulin Therapy in Type 1 and Type 2 Diabetes Mellitus: A Physiological Approach Toward Improved Metabolic Control
Current Pharmaceutical Design VaD - An Integrated Framework for Cognitive Rehabilitation
CNS & Neurological Disorders - Drug Targets Pharmacogenetics of Glucagon-like Peptide-1 Agonists for the Treatment of Type 2 Diabetes Mellitus
Current Clinical Pharmacology The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications
Current Pharmaceutical Design Comprehensive Evaluation and Clinical Application of Combined Redox Assay Methods to Determine Total Antioxidant Capacity
Current Analytical Chemistry Novel Validated RP-HPLC Method for Simultaneous Estimation of Valsartan & Gliclazide in Bulk and Dosage Forms
Current Pharmaceutical Analysis The Effect of TNFα-Inhibitors on Cardiovascular Events in Patients with Rheumatoid Arthritis: An Updated Systematic Review of the Literature
Current Rheumatology Reviews New Antihypertensive Drugs Under Development
Current Medicinal Chemistry Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate- Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) Signaling Pathways
Current Pharmaceutical Design Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs
Current Medicinal Chemistry Cognitive Dysfunction in Depression: Lessons Learned from Animal Models
CNS & Neurological Disorders - Drug Targets Glucose Transporters in Sex Steroid Hormone Related Cancer
Current Vascular Pharmacology Personalized Medicine in Psoriasis: Concept and Applications
Current Vascular Pharmacology HDL-C Levels and Cardiovascular Disease: More is not Always Better!
Recent Patents on Cardiovascular Drug Discovery HPTLC Method for the Determination of Metformin Hydrochloride, Saxagliptin Hydrochloride, and Dapagliflozin in Pharmaceuticals
Current Analytical Chemistry A Review of the Cardiovascular and Anti-Atherogenic Effects of Ghrelin
Current Pharmaceutical Design Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration
Current Topics in Medicinal Chemistry Perioperative Considerations in Diabetic Patients
Current Diabetes Reviews Deciphering Dual Antiplatelet Therapy in the Era of Drug-Eluting Coronary Stents
Current Drug Targets Anti-Inflammatory Properties of Drugs from saffron crocus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry