Abstract
The purine ring system is undoubtedly among the most ubiquitous of all the heterocyclic compounds. In recent years modified purine structures both of natural and synthetic origin have been a rich source of biologically active materials. The halogen at 6 position of the purine moiety of the (RS)-9 or 7-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-9H-or 7Hpurines shows an interesting reactivity which is presented and discussed. The anticarcinogenic potential of the target molecules is reported against the MCF-7 cancer cell line.
Keywords: Amination, antitumour compounds, benzodioxepins, purines, suzuki reaction, trifluoromethylation reaction
Mini-Reviews in Organic Chemistry
Title: Thermal N-9 → N-7 Isomerization of (6-Substituted)-9-(2,3-Dihydro-5H-1,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects
Volume: 5 Issue: 2
Author(s): M. A. Gallo, A. Espinosa and J. M. Campos
Affiliation:
Keywords: Amination, antitumour compounds, benzodioxepins, purines, suzuki reaction, trifluoromethylation reaction
Abstract: The purine ring system is undoubtedly among the most ubiquitous of all the heterocyclic compounds. In recent years modified purine structures both of natural and synthetic origin have been a rich source of biologically active materials. The halogen at 6 position of the purine moiety of the (RS)-9 or 7-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-9H-or 7Hpurines shows an interesting reactivity which is presented and discussed. The anticarcinogenic potential of the target molecules is reported against the MCF-7 cancer cell line.
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Gallo A. M., Espinosa A. and Campos M. J., Thermal N-9 → N-7 Isomerization of (6-Substituted)-9-(2,3-Dihydro-5H-1,4-Benzodioxepin-3-yl)-9H-Purines in Solution: Mechanistic Aspects, Mini-Reviews in Organic Chemistry 2008; 5 (2) . https://dx.doi.org/10.2174/157019308784223569
DOI https://dx.doi.org/10.2174/157019308784223569 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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