Abstract
Technology surrounding genomics, or the study of an organisms genome and its gene use, has advanced rapidly resulting in an abundance of readily available genomic data. Although genomics is extremely valuable, proteins are ultimately responsible for controlling most aspects of cellular function. The field of proteomics, or the study of the full array of proteins produced by an organism, has become the premier arena for the identification and characterization of proteins. Yet the task of characterizing a proteomic profile is more complex, in part because many unique proteins can be produced by the same gene product and because proteins have more diverse chemical structures making sequencing and identification more difficult. Proteomic profiles of a particular organism, tissue or cell are influenced by a variety of environmental stimuli, including those brought on by infectious disease. The intent of this review is to highlight applications of proteomics used in the study of pathogenesis, etiology and pathology of infectious disorders. While many infectious agents have been the target of proteomic studies, this review will focus on those infectious diseases which rank among the highest in worldwide mortalities, such as HIV/AIDS, tuberculosis, malaria, measles, and hepatitis.
Keywords: Proteomics, HIV, AIDS, tuberculosis, malaria, measles, hepatitis, meningitis
Infectious Disorders - Drug Targets
Title: The Use of Proteomics to Study Infectious Diseases
Volume: 8 Issue: 1
Author(s): E. O. List, D. E. Berryman, B. Bower, L. Sackmann-Sala, E. Gosney, J. Ding, S. Okada and J. J. Kopchick
Affiliation:
Keywords: Proteomics, HIV, AIDS, tuberculosis, malaria, measles, hepatitis, meningitis
Abstract: Technology surrounding genomics, or the study of an organisms genome and its gene use, has advanced rapidly resulting in an abundance of readily available genomic data. Although genomics is extremely valuable, proteins are ultimately responsible for controlling most aspects of cellular function. The field of proteomics, or the study of the full array of proteins produced by an organism, has become the premier arena for the identification and characterization of proteins. Yet the task of characterizing a proteomic profile is more complex, in part because many unique proteins can be produced by the same gene product and because proteins have more diverse chemical structures making sequencing and identification more difficult. Proteomic profiles of a particular organism, tissue or cell are influenced by a variety of environmental stimuli, including those brought on by infectious disease. The intent of this review is to highlight applications of proteomics used in the study of pathogenesis, etiology and pathology of infectious disorders. While many infectious agents have been the target of proteomic studies, this review will focus on those infectious diseases which rank among the highest in worldwide mortalities, such as HIV/AIDS, tuberculosis, malaria, measles, and hepatitis.
Export Options
About this article
Cite this article as:
List O. E., Berryman E. D., Bower B., Sackmann-Sala L., Gosney E., Ding J., Okada S. and Kopchick J. J., The Use of Proteomics to Study Infectious Diseases, Infectious Disorders - Drug Targets 2008; 8 (1) . https://dx.doi.org/10.2174/187152608784139640
DOI https://dx.doi.org/10.2174/187152608784139640 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Intraocular Immune Mechanisms in Uveitis
Current Immunology Reviews (Discontinued) Immunity to Tuberculosis and Novel Therapeutic Strategies
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Drug Susceptibility of the Mycobacterium Genus: In Vitro Tests and Clinical Implications
Current Clinical Pharmacology Synthesis and Antitubercular Evaluation on Novel 1-Ethyl-5-(hetero)aryl- 1,6-dihydropyrazine-2,3-dicarbonitriles and 3-Cyano-1-ethyl-5-(hetero) aryl-2(1H)-pyrazinones
Anti-Infective Agents Angiogenesis as a Therapeutic Target in Arthritis: Lessons from Oncology
Current Pharmaceutical Design Formulation of Ofloxacin Loaded Lipospheres with Improved Oral Bioavailability
Pharmaceutical Nanotechnology State of the Art Review and Report of New Tool for Drug Discovery
Current Topics in Medicinal Chemistry Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders
Current Topics in Medicinal Chemistry New Synthetic Antibiotics for the Treatment of Enterococcus and Campylobacter Infection
Current Topics in Medicinal Chemistry Enantioselective Organocatalytic Reactions with Isatin
Current Organic Chemistry Association of Low Vitamin D with Complications of HIV and AIDS: A literature Review
Infectious Disorders - Drug Targets Clinical Development of Cationic Antimicrobial Peptides: From Natural to Novel Antibiotics
Current Drug Targets - Infectious Disorders Potential Use of Dendritic Cells for Anti-Atherosclerotic Therapy
Current Pharmaceutical Design Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Proteasome Structure, Function, and Lessons Learned from Beta-Lactone Inhibitors
Current Topics in Medicinal Chemistry Chemical Constituents of Plants from the Genus Valeriana
Mini-Reviews in Organic Chemistry Prospects for Clinical Introduction of Nitroimidazole Antibiotics for the Treatment of Tuberculosis
Current Pharmaceutical Design P2X7 Receptors: Channels, Pores and More
CNS & Neurological Disorders - Drug Targets Micelle-based Systems for Pulmonary Drug Delivery and Targeting
Drug Delivery Letters New Tuberculosis Drugs in Development
Current Topics in Medicinal Chemistry