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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents

Author(s): Marcus Vinicius Nora de Souza, Marcelle de Lima Ferreira, Thais Cristina Mendonca Nogueira, Raoni Schroeder Borges Goncalves, Monica Amado Peralta, Maria Cristina Silva Lourenco and Felipe Rodrigues Vicente

Volume 5, Issue 3, 2008

Page: [221 - 224] Pages: 4

DOI: 10.2174/157018008784083965

Price: $65

Abstract

The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μgmL. . The compounds 3g and 3k exhibited the respective activities of 25 and 50 μg/mL being a new class of compounds against tuberculosis.

Keywords: Tuberculosis, Multidrug-resistance, Thiophene, Thiopheneacetamides, Antimycobacterial activity, Alamar blue assay


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