Abstract
This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to “carbonyl stress” during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.
Keywords: Carbonyl stress, acrolein, protein adducts, hydralazine
Mini-Reviews in Medicinal Chemistry
Title: Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury
Volume: 8 Issue: 4
Author(s): P. C. Burcham, L. M. Kaminskas, D. Tan and S. M. Pyke
Affiliation:
Keywords: Carbonyl stress, acrolein, protein adducts, hydralazine
Abstract: This mini-review highlights the chemical and cytoprotective properties of various hydralazine analogues that block the induction of cell death by acrolein, a highly toxic contributor to “carbonyl stress” during a diverse range of human diseases. Recent work on the action of hydralazine against various carbonyl-mediated pathologies is also reviewed.
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Cite this article as:
Burcham C. P., Kaminskas M. L., Tan D. and Pyke M. S., Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury, Mini-Reviews in Medicinal Chemistry 2008; 8 (4) . https://dx.doi.org/10.2174/138955708783955953
DOI https://dx.doi.org/10.2174/138955708783955953 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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