Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

Title: Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

Volume: 5 Issue: 2

Author(s): Mei Xiao, Bi-Ke Zhu and Yu Lin Jiang

Affiliation:

Keywords: Uracil-DNA glycosylase, Small molecule inhibitors, Chemo-preventive agents, Melanoma, IgR3, MM200, Anticancer drugs

Abstract: Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.

Cite this article as:

Xiao Mei, Zhu Bi-Ke and Jiang Lin Yu, Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors, Letters in Drug Design & Discovery 2008; 5 (2) . https://dx.doi.org/10.2174/157018008783928445