Abstract
Negative and cognitive symptoms of schizophrenia remain difficult to treat. Many add-on medications to alleviate these symptoms have been proposed and investigated. In this inventory the various treatment strategies published since 1990 are being reviewed and categorised according to the pharmacological mechanism putatively involved. Notwithstanding the problems one experiences when comparing the applied measures for negative and cognitive symptoms, three clear recommendations for future research can be made viz. modulation of glutamatergic systems, blockade of serotonin 5-HT2 receptors and modulation of histaminergic systems. Strategies aimed at nAChR subtypes may also hold some promise.
Keywords: Schizophrenia, negative symptoms, cognitive dysfunction, add-on medication
Central Nervous System Agents in Medicinal Chemistry
Title: Antipsychotic Augmentation Strategies to Ameliorate Negative and Cognitive Symptoms in Schizophrenia; Implications for Future Research
Volume: 8 Issue: 1
Author(s): Gerben Duisterwinkel, F. J. Bosker, A. N. Scholte-Stalenhoef, M. Vervoort and H. Knegtering
Affiliation:
Keywords: Schizophrenia, negative symptoms, cognitive dysfunction, add-on medication
Abstract: Negative and cognitive symptoms of schizophrenia remain difficult to treat. Many add-on medications to alleviate these symptoms have been proposed and investigated. In this inventory the various treatment strategies published since 1990 are being reviewed and categorised according to the pharmacological mechanism putatively involved. Notwithstanding the problems one experiences when comparing the applied measures for negative and cognitive symptoms, three clear recommendations for future research can be made viz. modulation of glutamatergic systems, blockade of serotonin 5-HT2 receptors and modulation of histaminergic systems. Strategies aimed at nAChR subtypes may also hold some promise.
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Duisterwinkel Gerben, Bosker J. F., Scholte-Stalenhoef N. A., Vervoort M. and Knegtering H., Antipsychotic Augmentation Strategies to Ameliorate Negative and Cognitive Symptoms in Schizophrenia; Implications for Future Research, Central Nervous System Agents in Medicinal Chemistry 2008; 8 (1) . https://dx.doi.org/10.2174/187152408783790631
DOI https://dx.doi.org/10.2174/187152408783790631 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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