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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids

Author(s): V. F. Samanidou, M. K. Nika and I. N. Papadoyannis

Volume 8, Issue 3, 2008

Page: [256 - 275] Pages: 20

DOI: 10.2174/138955708783744038

Price: $65

Abstract

HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.

Keywords: HPLC, tricyclic antidepressants, monitoring, medicinal chemistry, biological fluids


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