Abstract
HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.
Keywords: HPLC, tricyclic antidepressants, monitoring, medicinal chemistry, biological fluids
Mini-Reviews in Medicinal Chemistry
Title: HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids
Volume: 8 Issue: 3
Author(s): V. F. Samanidou, M. K. Nika and I. N. Papadoyannis
Affiliation:
Keywords: HPLC, tricyclic antidepressants, monitoring, medicinal chemistry, biological fluids
Abstract: HPLC is discussed as an essential tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided.
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Cite this article as:
Samanidou F. V., Nika K. M. and Papadoyannis N. I., HPLC as a Tool in Medicinal Chemistry for the Monitoring of Tricyclic Antidepressants in Biofluids, Mini-Reviews in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/138955708783744038
DOI https://dx.doi.org/10.2174/138955708783744038 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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