Abstract
G pretein coupled-receptors (GPCR) have been shown to form heterodimers or heterooligomers with various biochemical and/or pharmacological activity that are distinct from those of the corresponding monomers or homomers. Recent in vitro and in vivo experimental data have also shown novel functional roles of several orphan GPCRs as modulatory units of heterodimers and potentials for development of heterodimer-selective clinical agents. In this review, we summarize essential and latest knowledge as to GPCR heterodimerizations and the current issues to be solved in the near future.
Keywords: GPCR, heterodimerization, signaling, conformation
Protein & Peptide Letters
Title: Recent Advances and Perceptions in Studies of Heterodimerization between G Protein-Coupled Receptors
Volume: 15 Issue: 3
Author(s): Honoo Satake and Tsubasa Sakai
Affiliation:
Keywords: GPCR, heterodimerization, signaling, conformation
Abstract: G pretein coupled-receptors (GPCR) have been shown to form heterodimers or heterooligomers with various biochemical and/or pharmacological activity that are distinct from those of the corresponding monomers or homomers. Recent in vitro and in vivo experimental data have also shown novel functional roles of several orphan GPCRs as modulatory units of heterodimers and potentials for development of heterodimer-selective clinical agents. In this review, we summarize essential and latest knowledge as to GPCR heterodimerizations and the current issues to be solved in the near future.
Export Options
About this article
Cite this article as:
Satake Honoo and Sakai Tsubasa, Recent Advances and Perceptions in Studies of Heterodimerization between G Protein-Coupled Receptors, Protein & Peptide Letters 2008; 15 (3) . https://dx.doi.org/10.2174/092986608783744207
DOI https://dx.doi.org/10.2174/092986608783744207 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-tumoral Properties of Endogenous Angiogenesis Inhibitors: A Case for Continued TIMP-2 Preclinical Development
Current Angiogenesis (Discontinued) A Genome-Wide Identification and Analysis of the Basic Helix-Loop-Helix Transcription Factors in Water Buffalo (Bubalus bubalis)
Current Proteomics Liver Enzymes: Potential Cardiovascular Risk Markers?
Current Pharmaceutical Design The Application of Fungal Beta-glucans for the Treatment of Colon Cancer
Anti-Cancer Agents in Medicinal Chemistry Pharmacological Benefits of Active Components of Natural Products Against Traumatic Brain Injury - A Review
Current Pharmacogenomics and Personalized Medicine Anti-inflammatory and Hypolipidemic Effect of Novel Conjugates with Trolox and Other Antioxidant Acids
Medicinal Chemistry Molecular Mechanisms of Action of Gas1 and its Possible Therapeutic Applications
Current Signal Transduction Therapy Advanced Methods for the Analysis of Testosterone
Current Medicinal Chemistry Editorial [ Angiogenesis: A Promising Treatment Option for Peripheral Arterial Disease ]
Current Vascular Pharmacology Endothelial Dysfunction, Obesity and Insulin Resistance
Current Vascular Pharmacology Role of Ghrelin in Drug Abuse and Reward-Relevant Behaviors: A Burgeoning Field and Gaps in the Literature
Current Drug Abuse Reviews β-Galactosidase – Excipients Interaction by Docking Simulation Studies
Letters in Drug Design & Discovery Perceived Barriers, Benefits, Facilitators, and Attitudes of Health Professionals Towards Multidisciplinary Team Care in Type 2 Diabetes Management: A Systematic Review
Current Diabetes Reviews Tumor-Targeting Peptides: Ligands for Molecular Imaging and Therapy
Anti-Cancer Agents in Medicinal Chemistry The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration
Current Stem Cell Research & Therapy The First Line of Defense Against Cardiac Hypertrophy
Current Molecular Medicine Human Microdialysis
Current Pharmaceutical Biotechnology Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects
Current Drug Metabolism mPEG-PLA Micelle for Delivery of Effective Parts of Andrographis Paniculata
Current Drug Delivery Early Cerebral Infarction Following Aneurysmal Subarachnoid Hemorrhage: Frequency, Risk Factors, Patterns, and Prognosis
Current Neurovascular Research