N-Myristoyltransferase: A Novel Target

M.   P.   Toraskar; K.   K.   Prasad; V.   J.   Kadam

Abstract

Myristoyl-CoA:Protein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid , myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for Anticancer, Antiviral and antifungal agents. Recent Nmyristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.

Keywords: N-myristoyltransferase, myristoylation, benzofurans, benzothiazoles, antifungal, Candida albicans, anticancer, antiviral