Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB

Title: Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB

Volume: 5 Issue: 1

Author(s): R. M. Riggs, R. K. Jennings, E. R. Derstine, T. M. Nguyen, T. Trinh and J. M. Riordan

Affiliation:

Keywords: Tuberculosis, Antimycobacterial, Structure-activity relationships

Abstract: Multi-drug resistant tuberculosis is a worldwide problem where despite treatment; mortality can range up to 18%. An N-aryl 2-aminothiazole-4-carboxamide derivative was identified as a lead compound in a Tuberculosis Coordinating Antimicrobial Acquisition Facility (TCAAF) screen. Synthesis and biological evaluation of additional analogs led to structure-activity relationships for activity against TB.

Cite this article as:

Riggs M. R., Jennings K. R., Derstine R. E., Nguyen M. T., Trinh T. and Riordan M. J., Synthesis and Evaluation of N-Aryl 2-Aminothiazole-4-Carboxamide Derivatives for Activity Against TB, Letters in Drug Design & Discovery 2008; 5 (1) . https://dx.doi.org/10.2174/157018008783406615