Abstract
Mental illness affects a quarter of the US population. Recently, it has been shown that new, carbohydrate-based drugs hold promise in the treatment of central nervous system (CNS) disorders. A variety of ways in which drugs of this sort may reduce the symptoms of epilepsy, depression and other affective disorders have been proposed, including: targeting the immune system, disrupting glycolysis, acting at different sites in the hypothalamic-pituitary-adrenal (HPA) axis, and targeting specific biochemical pathways such as the inositol pathway. In the present review, the structureactivity relationships (SARs) of a wide variety of CNS-active carbohydrates are presented.
Keywords: Glycolysis, topiramate, saponins, steroidal glycosides, capsular saccharides
Current Topics in Medicinal Chemistry
Title: Carbohydrate-Based Drugs in the Treatment of Epilepsy, Depression and Other Affective Disorders
Volume: 8 Issue: 2
Author(s): Cecilia H. Marzabadi and Ian Jamie Talisman
Affiliation:
Keywords: Glycolysis, topiramate, saponins, steroidal glycosides, capsular saccharides
Abstract: Mental illness affects a quarter of the US population. Recently, it has been shown that new, carbohydrate-based drugs hold promise in the treatment of central nervous system (CNS) disorders. A variety of ways in which drugs of this sort may reduce the symptoms of epilepsy, depression and other affective disorders have been proposed, including: targeting the immune system, disrupting glycolysis, acting at different sites in the hypothalamic-pituitary-adrenal (HPA) axis, and targeting specific biochemical pathways such as the inositol pathway. In the present review, the structureactivity relationships (SARs) of a wide variety of CNS-active carbohydrates are presented.
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Cite this article as:
Marzabadi H. Cecilia and Talisman Jamie Ian, Carbohydrate-Based Drugs in the Treatment of Epilepsy, Depression and Other Affective Disorders, Current Topics in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/156802608783378846
DOI https://dx.doi.org/10.2174/156802608783378846 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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