Abstract
Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.
Keywords: N-Glycosyl amine, N-glycosyl amide, N-glycosylated heterocycles
Current Topics in Medicinal Chemistry
Title: Pyranose N-Glycosyl Amines: Emerging Targets With Diverse Biological Potential
Volume: 8 Issue: 2
Author(s): Peter Norris
Affiliation:
Keywords: N-Glycosyl amine, N-glycosyl amide, N-glycosylated heterocycles
Abstract: Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.
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Cite this article as:
Norris Peter, Pyranose N-Glycosyl Amines: Emerging Targets With Diverse Biological Potential, Current Topics in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/156802608783378837
DOI https://dx.doi.org/10.2174/156802608783378837 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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